Green Housing Study: Boston Followup

项目总结/摘要 哮喘目前影响着美国近2200万成年人和儿童，并导致 直接和间接成本超过180亿美元/年。(CDC，2012年，AAFA，2012年） 哮喘的患病率和发病率在经济和种族上是惊人的， 在一些低收入城市地区，失业率超过25%。（Nicholas等人，（2005年） 改善医疗保健和采取干预措施，减少环境暴露， 这些社区意义重大。 为了研究家居环境的“绿色”改善潜力， 减少暴露于化学品和其他哮喘诱因在家里，中心为 疾病控制和预防中心（CDC）发起了绿色住房研究（GHS）。所报 根据征求建议书，全球统一制度的具体目标如下： 具体目标1对化学和生物污染物进行接触评估， 杀虫剂、挥发性有机化合物（VOCs）、真菌、室内过敏原（就种类和 浓度）与比较外壳中的。 a.测量表面擦拭样品中农药的内部水平;真菌和室内 灰尘样本中的过敏原;以及空气样本中的挥发性有机化合物。 B.比较挥发性有机化合物和杀虫剂的生物标志物水平（就品种和 浓度）从参与居民的绿色和比较住房。 具体目标2：研究居住在绿色住房与对照住房之间的关系， 哮喘发病率（例如，症状，急诊室就诊，药物使用，丢失 学校/工作日）的儿童与医生诊断的哮喘（年龄7-12岁）。调整数 将进行过敏致敏和环境烟草烟雾（ETS）。 2011年，建立了两个研究中心：波士顿和辛辛那提。实地考察始于 2011年夏季，目前正在进行基线评估。请求的 资金将为后续测量暴露和呼吸健康提供支持 参加GHS的儿童的结果。我们的项目团队是一个合作， 凭借哈佛公共管理学院的同事们的专业知识和资源， 健康（HSPH），塔夫茨医学院，波士顿医学中心和大学 马萨诸塞州，洛厄尔。到目前为止，我们的团队已经在所有领域发展了重要的专业知识， 程序，并已成功地实施了所有类别的主要研究活动。我们 拟议在2013年6月前完成所有6个月和12个月的后续实地工作。

Project Summary/Abstract Asthma currently affects nearly 22 million adults and children in the U.S., and results in direct and indirect costs exceeding $18 billion/year. (CDC, 2012, AAFA, 2012) Disparities in asthma prevalence and morbidity across economic and racial lines are striking, with prevalence rates exceeding 25% in some low-income urban areas. (Nicholas et al., 2005) The need for improvements in healthcare and for interventions which mitigate environmental exposures within these communities are significant. In order to examine the potential for "green" improvements to the home environment to reduce exposures to chemicals and other asthma triggers within the home, the Centers for Disease Control and Prevention (CDC) initiated the Green Housing Study (GHS). As stated in the RFP, the specific aims of the GHS are as follows: Specific Aim 1 To conduct an exposure assessment of chemical and biological contaminants, pesticides, volatile organic compounds (VOCs), fungi, indoor allergens (in terms of variety and concentration) in green vs. comparison housing. a. Measure interior levels of pesticides in surface wipe samples; fungi and indoor allergens in dust samples; and VOCs in air samples. b. Compare levels of biomarkers of VOCs and pesticides (in terms of variety and concentration) from the participating residents of green and comparison housing. Specific Aim 2 To examine the relationship between living in green vs. comparison housing and asthma morbidity (e.g., symptoms, emergency department visits, use of medications, lost school/work days) of children with doctor-diagnosed asthma (ages 7-12 years). Adjustments for allergic sensitization and environmental tobacco smoke (ETS) will be made. In 2011, two study sites were established: Boston and Cincinnati. Fieldwork began in the summer of 2011 and baseline assessments are being conduction currently. The requested funding will provide support for follow-up measurements of exposures and respiratory health outcomes of children who are enrolled in GHS. Our project team is a collaboration that builds upon the significant expertise and resources of colleagues from the Harvard School of Public Health (HSPH), Tufts School of Medicine, the Boston Medical Center and the University of Massachusetts, Lowell. To date, our team has developed significant expertise in all field procedures and has successfully implemented all categories of principal study activities. We propose to complete all 6- and 12-month follow-up fieldwork by June 2013.