Imaging Core

影像共享资源核心的目的是通过提供和支持最先进的分子、功能和解剖成像来支持创新的、多学科的、转化性研究。成像核心与加州大学洛杉矶分校前列腺癌孢子研究人员密切合作，在他们的临床前和临床研究中实施和整合生物成像，以开发关键的生物信息，促进前列腺癌的最佳检测、治疗和整体管理。成像核心提供各种临床前成像方式，包括microPET、microCT、光学(生物发光和荧光)和数字全身放射自显影。成像核心的临床组件提供多参数磁共振成像和磁共振光谱分析，以及无创生理和代谢成像的正电子发射断层扫描。此外，通过使用Artemis系统的MRI/US联合配准，或通过介入放射学的CT引导活检，可以进行有针对性的活检。成像共享资源核心的作用是帮助研究人员进行实验设计，开发标准化和量化的图像解释方法，并解决技术障碍。成像核心还与病理学核心密切合作，进行有针对性的组织采集。将这些活动集中在一个共享资源中可确保在孢子项目的临床组件中采用统一的方法和实施，这对项目的成功至关重要。

The purpose of the Imaging Shared Resource Core is to support innovative, multidisciplinary, translational research through the provision and support of state-of-the-art molecular, functional, and anatomical imaging. The Imaging Core works closely with UCLA Prostate SPORE investigators to implement and integrate biological imaging in their preclinical and clinical studies in order to develop key biological information to foster the optimal detection, treatment, and overall management of prostate cancer. The Imaging Core provides access to a diverse spectrum of preclinical imaging modalities, including microPET, microCT, optical (bioluminescence and fluorescence) and digital whole body autoradiography. The clinical component of the Imaging Core provides access to multiparametric MRI and MR Spectroscopy.and PET for noninvasive imaging of physiology and metabolism. In addition, targeted biopsies can be conducted using MRI/US coregistration using the Artemis system, or through CT-guided biopsy by interventional radiology. The role of the Imaging Shared Resource Core is to aid investigators in experimental design, develop standardized and quantitative approaches to image interpretation, and to solve technical hurdles. The Imaging Core also works closely with the Pathology core for targeted tissue acquisition. Centralization of these activities in a Shared Resource ensures a uniform approach and implementation across the clinical components of the SPORE projects and is critical to their success.