Training in Developmental Hematology

描述(由申请人提供)：对儿童血液疾病的研究为理解调节造血的基本机制提供了一个重要的范例。与成人血液病不同，许多儿科疾病是由控制血细胞发育或功能的固有遗传缺陷引起的。对许多儿童血液病的分子发病机制了解甚少。在加州大学洛杉矶分校，我们有大量的跨学科研究人员，他们的研究集中在与发育血液学相关的广泛主题上。因此，我们提出了一个独特的培训计划，通过整合各种学科，包括分子和细胞造血学、替代生物模型、干细胞移植、止血和血栓形成、输血医学、蛋白质组/基因组学新技术、血液恶性肿瘤、治疗学和数学建模，专门针对儿童血液疾病。鉴于儿科血液学内科科学家人数的减少，发展血液学的培训计划对于推动该领域的发展至关重要。在这项申请中，我们要求在5年内每年资助4名博士后研究员。研究员将是医学博士、医学博士或博士。学员将有机会在22个教职员工的实验室中进行研究。受训者将根据他们的学术潜力和研究成果从大约20至30名博士后研究员中挑选出来。任命的任期为两年，第二年的任命取决于进度报告。受训人员将被要求参加多学科杂志俱乐部、凝聚课程和研讨会。他们还将通过病理学系参加发育血液学的必修课程。儿科血液学/肿瘤学实习生将每6个月与他们的奖学金监督委员会会面，以监测进展和生产率。他们将在全国会议上介绍他们的工作。许多研究人员都有预先存在的合作和出版物。我们希望利用加州大学洛杉矶分校的优势，包括跨多个学科的研究人员的广度和深度，培养未来的研究人员和儿科血液学领域的领导者。

DESCRIPTION (provided by applicant): Studies in pediatric blood disorders provide an important paradigm for understanding the fundamental mechanisms regulating hematopoiesis. Unlike adult hematologic disorders, many pediatric diseases result from intrinsic genetic defects that control blood cell development or function. Very little is understood about the molecular pathogenesis of many of the hematologic diseases in children. At UCLA, we have a tremendous resource of interdisciplinary investigators whose research focuses on a wide spectrum of topics related to developmental hematology. Therefore, we propose a unique training program that focuses specifically on pediatric hematologic diseases by integrating a variety of disciplines, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, hemostasis and thrombosis, transfusion medicine, novel technologies in proteomics/genomics, hematologic malignancies, therapeutics, and mathematical modeling. Given the declining number of physician-scientists in Pediatric Hematology, a training program in Developmental Hematology is critical to advance the field. In this application, we seek funding for 4 postdoctoral fellows per year for 5 years. The fellows will be either MDs, MD/PhDs, or PhDs. Trainees will have the opportunity to develop research in one of the 22 faculty member's laboratories. Trainees will be selected from a pool of approximately 20 to 30 postdoctoral fellows based on their academic potential and research achievements. Appointments will be for two years, the second year appointment being dependent on a progress report. Trainees will be required to participate in multidisciplinary journal clubs, a course on coagulation, and seminars. They will also take a required course on Developmental Hematology through the Department of Pathology. Pediatric Hematology/Oncology trainees will be expected to meet with their Scholarship Oversight Committees every 6 months to monitor progress and productivity. They will present their work at national meetings. Many investigators have pre- existing collaborations and publications. We hope to utilize the strengths of UCLA, including the breadth and depth of investigators across many disciplines, to train future researchers and leaders in the field of Pediatric Hematology.