Pathobiology of mucosal/epithelial disease

描述（由申请人提供）：这是一个机构NRSA的竞争性更新申请，以支持四名医学博士和/或博士博士后的培训。在过去的十年中，美国国立卫生研究院赞助的这一奖项将为20名研究员提供支持，让他们在专注于上皮病理生物学领域的不同而综合的实验室中进行培训。我们已经完成了培养博士后在学术界成功发展的目标。在NRSA资助的受训者中，有11人已经从事基础科学、临床医学和大学教学工作。一个是科学课程评估员，一个是陆军研究员，还有一个是疾病控制中心委任军团的成员。其中两人正在接受高级研究培训。该计划的主要目标是为消化道粘膜疾病的病理生理学问题导向研究提供多学科培训，特别强调上皮生物学，包括上皮细胞功能，炎症，病原体相互作用和肿瘤。培训师资队伍由19名研究人员组成，他们拥有与这些研究领域相关的独立研究项目，为研究疾病的病理生理学提供现代分子、免疫学和细胞生物学方法方面的专业知识。有特别强调上皮生物学和免疫学，因为它涉及到胃肠道疾病。培训计划的结构旨在继续促进参与教师之间的互动，并为受训者提供访问所有实验室及其大量资源的机会。培训生将继续从全国的临床和研究生项目中选拔，重点是确定合格的未被充分代表的少数民族。培训计划的主要组成部分是由受训者在自己选择的实验室中进行独立研究。通过参加众多可用的研究会议、期刊俱乐部和研讨会，以及参加埃默里大学研究生课程提供的课程，提高了培训经验，其中许多课程由该培训计划的教师教授。

DESCRIPTION (provided by applicant): This is a competing renewal application for an institutional NRSA to support the training of four MD and/or PhD postdoctoral fellows. Over the past ten years, this NIH-sponsored award will have provided support for twenty fellows to train in a diverse yet integrated group of laboratories focused in the area of epithelial pathobiology. We have accomplished the goal of training postdoctoral fellows for successful careers in academia. Eleven of the trainees who have been supported by this NRSA have gone on to careers in basic science, clinical medicine, and university teaching. One is a science curriculum evaluator, one is a researcher for the Army, and one is a member of the Centers for Disease Control's Commissioned Corps. Two are pursuing advanced research training. The main goal of this program is to provide multidisciplinary training in problem-oriented research on the pathophysiology of mucosal disease of the alimentary tract with special emphasis on epithelial biology, including epithelial cell function, inflammation, pathogen interactions and neoplasia. The training faculty consists of nineteen investigators with independent research programs related to these areas of study who provide expertise in modern molecular, immunologic, and cell biologic approaches for studying the pathophysiology of disease. There exists particular emphasis on epithelial biology and immunology as it relates to disorders of the gastrointestinal tract. The structure of the training program is designed to continue to promote interactions among participating faculty and to provide trainees access to all of the laboratories and their considerable resources. Trainees will continue to be selected from clinical and graduate programs nationwide with emphasis on identifying qualified underrepresented minorities. The major component of the training program is independent research carried out by trainees in a laboratory of their choice. The training experience is enhanced by attendance at numerous available research conferences, journal clubs, and seminars, as well as attendance at courses provided by the graduate program at Emory, many of which are taught by the faculty of this training program.