Research Training in Pediatric Endocrinology

申请者描述(由申请人提供)：本申请是为匹兹堡大学儿童医院(CHP)匹兹堡大学儿科(UOP)儿科儿童内分泌学和糖尿病博士后研究培训的竞争性续签。这项为期14年的研究培训计划的目标是在儿科内分泌学的分子、细胞、生理、遗传、生化或流行病学方面提供最先进的培训，以确保从该计划毕业的内科科学家为翻译研究中富有成效的学术生涯做好充分准备，这些研究与他们选择的儿科内分泌学和糖尿病的任何方面有关，在大学里有导师的专业知识。这一著名的长期奖学金项目的大多数毕业生都是全职学术职位，其中许多人担任研究领导职位，除了强制性的临床奖学金年度培训外，该项目还需要两到三年的指导性研究(基础科学或临床)。儿科内分泌学和糖尿病分部的教职员工兴趣广泛，是积极的研究人员，其中大多数是由赠款资助的，并与UOP和卡内基梅隆大学的其他教职员工和部门广泛互动。虽然临床培训围绕着中心的儿科内分泌科、糖尿病和肥胖科进行，但随后的研究年度将由研究员从科内外的研究导师名单中选择的主要导师来监督，具体取决于研究员的兴趣。所有研究部导师都是公认的研究人员，他们之所以被选中，是因为他们的研究具有直接的翻译相关性和高水平，他们在培训医学博士和博士科学家方面的杰出记录，他们在获得外部资金方面的长期生产力和成功，以及他们对跨学科项目的兴趣。除了一名主要的研究导师外，每个受训人员还将受到一个指导委员会的监督，该委员会包括项目主任，以监督和评估他/她的科学进步和职业发展。实习生将与其他医学博士、博士、医学博士/博士、博士后或博士后实习生并肩工作。定期评估，加上正式的课程工作，将为每个受训者的科学努力提供严格的智力基础。卫生防护中心和医学院对儿科研究的机构承诺是巨大的。UPMC和CHP承诺在未来三年内每年提供750万美元，包括2008年12月开放的一座新的最先进的儿科研究大楼。因此，该计划的总体成就、其关键的知识质量以及在CHP和UOP的巨大资源使其成为一个杰出的计划，以培训急需的儿科内分泌内分泌内科医生-科学家，鼓励他们过渡到K奖项，并培养他们作为独立的R01资助的研究人员的成功。随着国家对儿科内分泌学的兴趣与日俱增，正如申请者数量所反映的那样，我们预计这一研究培训计划将提供一种机制，通过该机制，当代内科科学家将获得在翻译研究中成功和富有成效的学术生涯所需的基本工具。相关性(见说明)：这个由T-32资助了14年的儿科内分泌和糖尿病培训项目，培养出了一支国内和国际公认的儿科内分泌研究队伍，其中包括6名儿科主任、9名科长和2名劳森·威尔金斯儿科内分泌学会主席。因此，我们的项目传统上一直是美国儿科内分泌学家的主要提供者。该项目是NIDDK资助的仅有的16个儿科、内分泌/糖尿病培训补助金之一，其毕业生对该子专业的学术未来至关重要。

DESCRIPTION (provided by applicant): This application is for the competitive renewal of the post-doctoral research training pediatric endocrinology and diabetes at the Children's Hospital of Pittsburgh (CHP) of UPMC, Department of Pediatrics, University of Pittsburgh (UOP). The goal of this 14 year research training program is to provide state-of-the- art training in the molecular, cellular, physiologic, genetic, biochemical or epidemiologic aspects of pediatric endocrinology to ensure that the physician-scientists who graduate from this program are well prepared for productive academic careers in translational research related to their choice of any aspect of pediatric endocrinology and diabetes for which there is mentorship expertise at the university. The majority of graduates of this well known long established fellowship program are in full-time academic positions with many in research leadership positions, The program entails two to three years of mentored research (basic science or clinical) in addition to the mandated clinical year of fellowship training. The faculty of the Division of Pediatric Endocrinology and Diabetes has diverse interests, are active investigators, most of whom are grant funded, and are widely interactive with other faculty and components of the UOP and Carnegie Mellon University. While clinical training revolves around the Division of Pediatric Endocrinology, Diabetes, and Obesity at the CHP, subsequent research years will be supervised by a primary mentor selected by the fellow from the research mentor list within or outside the division, depending on the interest of the fellow. All Research Faculty Mentors are established investigators, selected because of the immediate translational relevance and high caliber of their research, their outstanding records of training M.D. and Ph.D. scientists, their long-term productivity and success in securing extramural funding, and their interest in interdisciplinary projects. In addition to a primary research mentor, each trainee will be supervised by a mentorship committee, including the program directors, to oversee and evaluate his/her scientific progress and career development. Trainees will work side-by-side with other M.D., Ph.D., M.D./Ph.D. pre-doctoral or post-doctoral trainees. Periodic evaluations, coupled with formal course work, will provide a rigorous intellectual foundation for each trainee's scientific endeavors. The institutional commitment to pediatric research at CHP and the School of Medicine has been substantial. The UPMC and the CHP commitment is $7.5 million each year for the next 3 years, including the Dec 2008 opening of a new state of the art pediatric research building. Thus, the overall achievements of this program, its critical intellectual mass, and the tremendous resources at the CHP and the UOP have made this an outstanding program to train much needed pediatric endocrine physician-scientists, encourage their transition to K awards,and cultivate their success as independent R01 funded investigators. With increasing national interest in pediatric endocrinology, as reflected by the numbers of applicants, we anticipate that this research training program will provide a mechanism through which contemporary physician-scientists will obtain the tools fundamental for successful and productive academic careers in translational research. RELEVANCE (See instructions): This pediatric endocrine and diabetes training program, funded by a T-32 for the past 14 years, has produced a cadre of nationally and internationally recognized pediatric endocrine researchers including 6 Chairs of pediatrics, 9 Division Chiefs and 2 Presidents of the Lawson Wilkins Pediatric Endocrine Society. Our program, therefore, has traditionally been a major provider of pediatric endocrinologists in the USA. This program is one of only 16 NIDDK funded pediatric ^endocrine/diabetes training grants, whose graduates are essential to the academic future of the subspecialty.