Exergaming Intervention and Breast Cancer Biomarkers in Black Women

描述（由申请人提供）：肥胖本身是一个重要的公共卫生问题，与绝经后乳腺癌发病率和死亡率增加有关。这项研究提案将评估一种新的方法来改善黑人妇女的身体活动，他们通常比大多数其他种族和族裔群体的妇女身体活动较少，超重和肥胖。在这项研究中，我们将使用一种新的游戏干预策略，并评估其对体重和肥胖相关生物标志物，胰岛素相关途径和炎症的影响。我们提出了一个为期6个月的两组随机临床干预试验，使用视频游戏与对照组相比。我们将100名久坐不动的超重或肥胖的黑人女性随机分为Wii Fit运动干预组和对照组。本研究的具体目的是：（1）在社区环境中研究运动游戏干预的可行性和可接受性。我们将评估总体累积和对干预方案的依从性;（2）探索使用Wii Fit的运动游戏对久坐不动和超重或肥胖的黑人女性的心血管健康和体脂百分比研究终点的干预主要影响。据我们所知，这是第一项研究调查视频游戏干预成人;（3）检查收集生物标本的可行性， 以社区为基础的设置;和（4）探索运动干预对生物标志物的影响。

DESCRIPTION (provided by applicant): Obesity itself is a significant public health problem and is associated with increased postmenopausal breast cancer incidence and mortality. This research proposal will assess a novel method to improve physical activity in Black women, who are generally less physically active and more overweight and obese than women of most other racial and ethnic groups. In this study we will use a novel gaming intervention strategy and assess its impact on weight and biomarkers related to obesity, insulin-related pathways and inflammation. We propose a 6 month two-arm randomized clinical intervention trial using video gaming compared to a control group. We will randomize 100 Black sedentary overweight or obese women to either the Wii Fit exercise intervention arm or the control arm. The Specific Aims of the study are: (1) to examine the feasibility and acceptability of an exergaming intervention in a community-based setting. We will assess overall accrual and adherence to the intervention regimen; (2) to explore intervention main effects of exergaming using Wii Fit on study endpoints of cardiovascular fitness and percent body fat in Black women who are sedentary and overweight or obese. To our knowledge, this is the first study investigating a video gaming intervention in adults; (3) to examine the feasibility of collecting biospecimens in a community-based setting; and (4) to explore the impact of the exergaming intervention on biomarkers.