Biorepository and Biospecimen

项目SuIVIMARY(请参阅说明)： 2008年，OSUCCC将OSUCCC组织采购共享资源重组为生物库和生物检疫资源(BBR)。生物库和生物质谱库资源的目标是提供一个组织良好和集中化的生物库，满足NCI为癌症研究提供高质量生物质谱库的最佳实践。BBR由Scott Jewell博士领导，他在纸巾采购和银行业务的政策、管理和运营方面拥有丰富的经验。BBR 监督OSUCCC研究人员从实体肿瘤中采购恶性、良性、患病和未受累(正常)的组织，并已扩展为一个中央生物标本银行系统，在征得患者普遍知情同意的情况下捐赠生物标本(组织、血液和液体)和注解的临床数据，供未来研究使用。使用caGRID技术，这些标本与带注释的患者健康和医疗信息相关联，从而提高了这些信息的质量和可用性 用于研究的生物标记物。 BBR在过去10个月中收集了超过10,000个样本。自患者知情同意开始以来，另外还有2,500+个组织样本供调查人员立即使用。在本报告所述期间(2004-2009年)，BBR向OSUCCC的所有六个科学项目提供了11,000多个组织标本。BBR的重要功能包括：在注册时获得患者知情同意的同意团队；注释为 生物检疫剂；集中管理生物检疫剂的收集、加工和储存；资源的安全和保护，如空的备用冰柜、用于电力后备保护的柴油发电机、对所有冰柜的全天候监测，以及一个应急小组。 BBR利用caTIseSuite(一个caBIG应用程序)来记录和监控生物存储库库存。一种基于网络的应用程序已经开发出来，它将允许研究人员确定BBR中是否存在具有特定表型特征的组织。随着知情同意扩展到所有临床地点，这将 创建与带注释的临床数据相关联的可用研究生物样本的庞大存储库，提供 为OSUCCC调查人员提供无与伦比的资源。杰出的机构支持对 实施普遍知情同意程序，并确保继续增长和 这一高度重视的共享资源的成功。 在过去的一年里，尽管75.26%的BBR使用来自CCSG同行审查，但资金来自OSUCCC 调查人员和OSUCCC的总体使用率为96.77%，只有24.9%的BBR预算支持来自 来自CCSG的。

PROJECT SUIVIMARY (See instructions): In 2008 the OSUCCC reorganized the OSUCCC Tissue Procurement Shared Resource into the Biorepository and Biospecimen Resource (BBR). The goal of the Biorepository and Biospecimen Resource is to provide a well-organized and centralized biorepository that meets the best practices of the NCI for high quality biospecimens for cancer research. The BBR is directed by Dr. Scott Jewell who has extensive experience in the policy, management and operations in tissue procurement and banking. The BBR oversees the procurement of malignant, benign, diseased and uninvolved (normal) tissues from solid tumors for OSUCCC researchers and has expanded into a centralized biospecimen banking system with universal patient informed consent for the donation of biospecimens (tissues, bloods, and fluids) and annotated clinical data for future research. Using caGRID technology, these specimens are linked with annotated patient health and medical information, thereby enhancing the quality and usability of these biospecimens for research. The BBR has collected over 10,000 samples in the last 10 months .since the inception of patient informed consent and an additional 2,500+ tissue specimens for immediate use to investigators. During this reporting period (2004-2009) the BBR provided all six OSUCCC Scientific Programs with more than 11,000 tissue specimens. Valued features of the BBR include: a consent team that obtains patient informed consent at the point of registration; patient medical and health information that is annotated to the biospecimen; centralized management of the collection; processing and storage of the biospecimens; and security and protection of the resource, such as empty backup freezers, diesel generator for electrical backup protection, 24/7 monitoring of all freezers, and an emergency response team. The BBR utilizes caTissueSuite (a caBIG application) to record and monitor the biorepository inventory. A web-based application has been developed that will allow researchers to determine if tissue exists in the BBR with particular phenotypic characteristics. As informed consent expands to all clinical sites, this will create a vast repository of viable research biospecimens linked with annotated clinical data, providing an unparalleled resource for OSUCCC investigators. Outstanding institutional support has been critical to the implementation of the universal informed consent process and has ensured the continued growth and success of this highly valued shared resource. This past year, although 75.26% of the BBR usage was from CCSG peer-reviewed, funded OSUCCC investigators and overall OSUCCC usage was 96.77%, only 24.9% of the BBR budgetary support came from the CCSG.