Tumor and Circulating Markers as Links Between Obesity and Lethal Prostate Cance

肥胖是全球公共健康问题，三分之二的美国男性超重或肥胖。对于前列腺癌患者来说，肥胖的流行令人担忧，因为在确诊前或确诊时超重的男性，其生化复发和癌症特有死亡率的风险会增加。肥胖和致命的前列腺癌之间的联系存在几个悬而未决的问题，需要这些问题的答案来阐明前列腺癌患者的翻译潜力。 我们的研究旨在阐明肥胖和致命性前列腺癌之间联系的潜在机制，并确定更容易受到肥胖环境影响的患者亚群。我们假设肥胖可能通过局部肿瘤效应起作用

Obesity is a public health problem globally, and two-thirds of US men are overweight or obese. For prostate cancer patients, the obesity epidemic is of concern since men who are overweight before or at the time of diagnosis are at increased risk of biochemical recurrence and cancer-specific mortality. There are several outstanding questions underlying the association between obesity and lethal prostate cancer whose answers are needed to shed light on the translational potential among prostate cancer patients. Our study aims to elucidate mechanisms underlying the link between obesity and lethal prostate cancer and identify patient subgroups more susceptible to the obesity milieu. We hypothesize that obesity may act through local tumor effects which are