2013 Stress Proteins in Growth, Development & Disease Gordon Research Conference

描述（由申请人提供）：细胞蛋白质组不断暴露于各种各样的毒性应激。这些压力包括外部压力，如高温、辐射损伤和药物作用，以及细胞增殖、分化、炎症和衰老过程中遇到的生理压力。在所有生物体中，应激反应的诱导对于维持蛋白质稳态至关重要，应激反应的调节在寿命调节和衰老相关疾病（如阿尔茨海默病、帕金森病和亨廷顿病）中起着至关重要的作用。2013年关于“生长、发育和疾病中的应激蛋白”的戈登会议正在成为该研究领域最令人兴奋和最重要的会议之一。它将突出该领域的许多前沿进展，强调广泛的主题，包括与应激传感、信号传导和基因表达有关的令人兴奋的发展，蛋白质折叠和构象疾病，应激基因在代谢、生长和发育中的作用，应激基因对感染和病理生理状态的调节，应激的细胞生物学，以及应激在衰老中的作用。本次会议是本系列的第七次会议，将于7月7日至12日在佛蒙特州西多佛的雪山度假村举行。本次会议的主席是Judith friedman博士（斯坦福大学，加州斯坦福），联合主席是Ursula Jakob博士（密歇根大学，密歇根州安娜堡）。到目前为止，已有34位国际知名的演讲者承诺出席2013年的会议并发表演讲，其中包括9位女性和1位非洲裔美国人。此外，将作出重大努力，增加与会者的多样性，带来更多与会者

DESCRIPTION (provided by applicant): The cellular proteome is constantly exposed to a wide variety of toxic stresses. These include external stresses, such as elevated temperatures, radiation damage and pharmacological agents as well as physiological stresses encountered during cellular proliferation, differentiation, inflammation and aging. In all organisms, inductionof the stress response is essential for the maintenance of protein homeostasis and modulation of the stress response plays a critical role in life-span regulation and aging-related diseases such as Alzheimer's, Parkinson's and Huntington's disease. The 2013 Gordon Conference on "Stress Proteins in Growth, Development & Disease" is shaping up to be one of the most exciting and important meetings in this research area. It will highlight the many cutting edge advances in the field, emphasizing a broad range of topics, including exciting developments related to stress sensing, signaling, and gene expression, diseases of protein folding and conformation, roles of stress genes in metabolism, growth and development, stress gene modulation of infection and pathophysiological states, the cell biology of stress, and the roles of stress in aging. This conference, which is the seventh in this series, will be held July 7th-12th at the Mount Snow Resort in West Dover, Vermont. The chair of this meeting is Dr. Judith Frydman (Stanford University, Stanford, CA) and the co-chair is Dr. Ursula Jakob (University of Michigan, Ann Arbor, MI). Thus far, 34 internationally recognized speakers have committed to attending and speaking at the 2013 meeting, including 9 women and one African- American. Moreover, significant effort will be undertaken to increase the diversity of meeting attendees, to bring more scientists into the stress protein field, and to catalyze the formation of new collaborations. To this end, the schedule has been prepared so that 10 speaking slots will be chosen from abstracts submitted for poster presentations, and preference will be given to younger scientists and to those from under-represented groups. The meeting schedule will also be prepared to ensure that new and emerging themes in stress biology and different model systems are equally represented. In addition, meeting attendance will be "capped" at 200 to facilitate effective interactions and discussions. The formal scientific program together with more informal discussions will enhance the dissemination of new information and the formation of new collaborations, which are invaluable for deeper understanding of the versatile roles of stress proteins in human health, aging and disease.