Plasma Amyloid-beta Peptides, Depression and Alzheimer's Disease in the Homebound

BothAlzheimer‘sdisease(AD)anddepressionhavebecomeincreasinglymoreprevalentin 家庭受到束缚，导致发病率、护理和家庭安置增加 死亡率，thanwhatarefoundinthegeneralelderlypopulation.Ourcross！sectionalstudyofan EstablishedhomeboundpopulationintheBostonareahasfoundthatlowplasmaamyloid！b42 (Ab42)isassociatedwithdepressionindependentlyofcardiovasculardisease.Wefurther FoundthatdepressionwithlowAb42combinedwithhighAb40inplasmaisassociatedwith Poormemory.SimilarlyotherresearchstudieshaveshownthatahighplasmaA¿40/A¿42 RatiosignificantlyincreasedtheriskofAD.MultiplestudiesdemonstratethatplasmaA¿ Correlateswithcerebralspinalfluid(CSF)A¿whencognitionisnormal，平衡 DisappearsaftertheADcognitivesymptomsoccur.Wehypothesizetheexistenceofa 我们已经退役的potentialdepressionsubtypeassociatedwithAbpeptidesinplasma， “amyloid！associateddepression”.ThepurposeofthisR01applicationistovalidatethe Existenceofamyloid！associateddepressiondefinedbyahighplasmaA¿40/A¿42ratio，和TO InvestigatewhetherthisdepressionsubtypeisaprodromaldepressionofAD.Theproposalis 基于可恢复的人口，并有一个目标：Aim1记录的记忆力下降 Prospectivelyinthosewithamyloid！associateddepressionvs.thosewithnon！amyloid Depressionvs.thecontrols.Aim2istoinvestigatetherelationshipbetweenplasmaA¿and 阿尔茨海默病的中枢神经系统生物标志物CSFA在不同抑郁症中的作用 Subgroups.Ourlong！termgoalistoidentifyprodromalsignsofADtohelpfacilitateearly Treatmentofthediseaseinthehomeboundelderlypopulation.

BothAlzheimer'sdisease(AD)anddepressionhavebecomeincreasinglymoreprevalentin thehomeboundelderly,leadingtoincreasedratesofmorbidity,nursinghomeplacementand mortality,thanwhatarefoundinthegeneralelderlypopulation.Ourcross!sectionalstudyofan establishedhomeboundpopulationintheBostonareahasfoundthatlowplasmaamyloid!b42 (Ab42)isassociatedwithdepressionindependentlyofcardiovasculardisease.Wefurther foundthatdepressionwithlowAb42combinedwithhighAb40inplasmaisassociatedwith poormemory.SimilarlyotherresearchstudieshaveshownthatahighplasmaA¿40/A¿42 ratiosignificantlyincreasedtheriskofAD.MultiplestudiesdemonstratethatplasmaA¿ correlateswithcerebralspinalfluid(CSF)A¿whencognitionisnormal,butthisequilibrium disappearsaftertheADcognitivesymptomsoccur.Wehypothesizetheexistenceofa potentialdepressionsubtypeassociatedwithAbpeptidesinplasma,whichwehavetermed "amyloid!associateddepression".ThepurposeofthisR01applicationistovalidatethe existenceofamyloid!associateddepressiondefinedbyahighplasmaA¿40/A¿42ratio,andto investigatewhetherthisdepressionsubtypeisaprodromaldepressionofAD.Theproposalis basedonourestablishedpopulation,andhastwoaims:Aim1istodocumentmemorydecline prospectivelyinthosewithamyloid!associateddepressionvs.thosewithnon!amyloid depressionvs.thecontrols.Aim2istoinvestigatetherelationshipbetweenplasmaA¿and CSFA¿,acentralnervoussystem(CNS)biomarkerofAD,inthedifferentdepression subgroups.Ourlong!termgoalistoidentifyprodromalsignsofADtohelpfacilitateearly treatmentofthediseaseinthehomeboundelderlypopulation.