Methods Core p350-370

方法核心（MC）将提供集中服务，以解决研究问题和问题 与TCORS研究项目的研究设计、测量、分析和方法培训有关， 其他核心和调查员MC将确保测量和数据收集方法 改进以适用于各种弱势群体，还将积极改进和调整数据 收集工具，用于不同的弱势群体，提供内部服务， 对其他TCORS的价值。MC将提供有关识别，开发和 验证仪器，并提供最先进的，文化上适当的采访，生理， 社会心理学、基于社区的行为、档案、GIS和观察措施、数据管理， 统计分析、培训以及方法和统计咨询。MC将维护一个网站- 基于系统，提供数据的中央存储库，并促进中心之间的仪器和文件共享 研究者、监管科学培训生和其他受资助的TCORS。MC核心成员带来专业知识 在特定学科的测量，设计和分析技术，如先进的方法， 统计建模，心理测量学分析，定性数据分析，社区参与 研究（CBPR）方法和行为数据收集。核心方法的具体目标是： 设计和取样。协助审查研究设计方案，并制定和实施 为中心研究和核心提供适当的抽样方法，并就以下方面向核心人群提供建议： 最大限度地提高参与率和跟踪率并最大限度地减少流失的程序。 测量验证和开发。协助确定现有措施， 开发和验证可在各个项目中应用的新措施。 数据管理功能开发和维护一个网站，作为一个集中的，安全的网络系统， 促进各项目之间的工具和数据集共享，为项目进行数据输入。 数据分析为USC TCORS项目和监管科学提供统计和计算机支持 培训学员，并与其他TCORS分享新的统计方法。 咨询、培训和融合。为研究者和工作人员提供测量咨询 和分析战略，并与 研究培训和教育核心。 相关性（参见说明）： 方法核心协调现有的资源、程序和专门知识，使所有人都能利用这些资源、程序和专门知识 中心的研究者，并为所有研究提供研究设计、统计分析和 测量发展。方法核心将有助于确保南加州大学TCORS的研究是 尽可能多地提供信息。

The Methods Core (MC) will provide centralized services to address research questions and issues pertaining to study design, measurement, analysis, and methods training to the TCORS research projects, other cores, and investigators. The MC will assure that measurement and data collection approaches are refined to be useful in various vulnerable populations and will also pro-actively refine and adapt data collection tools for use in diverse vulnerable populations, providing an internal service and one that will be of value to the other TCORS. The MC will offer services and consultation on identification, development and validation of instruments, and provision of state-of-the-art, culturally appropriate interview, physiological, psychosocial, behavioral community-based, archival, GIS, and observational measures, data management, statistical analysis, training and methodological and statistical consultation. The MC will maintain a web- based system to provide a central repository for data and facilitate instrument and file sharing among Center investigators, regulatory science trainees, and other funded TCORS. The MC core members bring expertise in discipline-specific measurement, design, and analytic techniques, such as advanced methodologies, statistical modeling, psychometrics analysis, qualitative data analysis, community-based participatory research (CBPR) methods, and behavioral data collection. The Specific Aims of the Methods Core are: Design and Sampling. To assist in the review of research design protocols and to develop and implement appropriate sampling methodology for center studies and cores and to advise the Population Core on procedures for maximizing participation and tracking rates and minimizing attrition. Measurement Validation and Development. To assist in the identification of existing measures and development and validation of new measures that can be applied across projects. Data Management. To develop and maintain a website to serve as a centralized, secure web system to facilitate sharing of instruments and data sets across projects, conduct data entry for the projects. Data Analysis. To provide statistical and computer support for USC TCORS projects and regulatory science trainees, and to share new statistical methods with other TCORSs. Consultation, Training and Integration. To provide consulting to investigators and staff in measurement and analysis strategies, and collaborate in training in regulatory science methodologies with the Research Training and Education Core. RELEVANCE (See instructions): The Methods Core coordinates existing resources, procedures and expertise to make them available to all the investigators in the center, and provides guidance to all studies on study design, statistical analysis, and measurement development. The Methods Core will help to assure that the research of the USC TCORS is as informative as possible.