CSHL Eukaryotic DNA Replication Conference

描述（申请人提供）：：2013真核DNA复制和基因组维护会议本次会议将是第14届真核DNA复制和基因组维护两年一度的会议，自1987年9月以来，每两年在冷泉港举行一次非常成功的会议。这是唯一定期举行的会议，专门专注于真核DNA复制。由于这一重点，会议在我们对真核DNA复制过程及其如何整合到细胞分裂周期的理解的快速增长中发挥了重要作用。今年的会议将致力于与染色体复制，结构和功能相关的基础研究主题，并将包括细胞周期和生长控制，基因组扩增以及复制装置对DNA损伤的反应等生物学研究的重要领域。从2007年的会议开始，我们越来越强调DNA复制在DNA损伤和复制应激反应中的核心作用，以及细胞用来最大限度地减少DNA复制对基因组完整性的威胁的策略。DNA复制和DNA损伤反应领域的快速融合使这是一个及时的会议。会议的形式将确保面对面交流和讨论最近的成果，这将促进进展和协作。大力鼓励青年研究人员、少数民族科学家和女科学家的参与。 2013年会议将包括一系列不同的主题、系统和方法，包括以下研究：（1）酵母、果蝇、非洲爪蟾和哺乳动物细胞等多种生物体中的染色体复制和基因扩增;（2）病毒染色体的复制，包括SV 40、多瘤病毒、巨细胞病毒、疱疹病毒、乳头瘤病毒和EB病毒;（3）细胞周期中DNA复制的控制;（4）控制复制的染色体元件（包括复制起点和端粒）的结构和功能;（5）DNA复制与细胞周期、染色质修饰、发育和癌症之间的联系;（6）控制基因组完整性的机制，包括DNA复制检查点和复制后DNA修复;（7）新的方法，包括基因组学，系统生物学和单分子研究。由于DNA复制对细胞分裂至关重要，不受控制的生长是肿瘤的标志，S期是化疗和放疗的主要靶点，DNA复制中的错误导致基因组不稳定，因此本次会议与癌症研究的相关性，并最终改善治疗，不能过分强调。 DNA的复制是所有（真核）生命的基本过程。本次会议将重点了解这一过程发生的机制，以及DNA复制如何有助于基因组稳定性和维持细胞的表观遗传状态。本次会议的知识价值包括为处于科学生涯各个阶段的领先研究人员提供分享和讨论他们最新成果和概念的机会。在口头和海报会议上进行的非正式同行评议在提供快速反馈方面非常宝贵，这将有效地指导和加速未来的研究。这次会议 还为学习和建立合作提供了充足的机会-没有计划平行会议，因此所有与会者都有共同的经验，而僻静的场地最大限度地提高了富有成效的科学交流的可能性。 大型会议通常可以在其领域产生重大影响。这次会议的独特之处在于，年轻科学家的积极参与，他们将特别受益于展示他们最新想法的机会。会议档案（可通过互联网访问的领先视频档案）允许与会者与无法参加会议的同事分享会议的各个方面，同时保护演讲作者提交未发表研究的权利。

DESCRIPTION (provided by applicant):: 2013 CONFERENCE ON EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE This conference will be the 14th biennial meeting on Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every second year since September 1987. It is the only regularly occurring meeting that is exclusively focused on eukaryotic DNA replication. Because of this focus, the meeting has played a major role in the rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle. This year's conference will be devoted to fundamental research topics related to chromosome duplication, structure and function, and will include important areas of biological research in the areas of cell cycle and growth control, genomic amplification, and the response of the replication apparatus to DNA damage. Starting with the 2007 meeting, we placed an increased emphasis on the central role of DNA replication in the DNA damage and replication stress response and the strategies used by cells to minimize the threats to genomic integrity arising from DNA replication. The rapid convergence of the DNA replication and DNA damage response fields makes this a timely meeting. The format of the meeting will ensure that recent results will be communicated and discussed face-to-face, which will enhance progress and collaboration. The participation of young investigators and minority and women scientists is strongly encouraged. The 2013 meeting will include a diverse array of topics, systems, and approaches including studies of: (1) chromosomal replication and gene amplification in organisms as diverse as yeast, Drosophila, Xenopus and mammalian cells; (2) the replication of viral chromosomes, including SV40, polyomavirus, cytomegalovirus, herpesvirus, papillomaviruses, and Epstein-Barr virus; (3) control of DNA replication in the cell cycle; (4) structure and function of the chromosomal elements controlling replication including origins of replication and telomeres; (5) connections between DNA replication and the cell cycle, chromatin modifications, development, and cancer; (6) mechanisms that control genomic integrity including DNA replication checkpoints and post-replication DNA repair; (7) novel approaches including genomics, systems biology, and single molecule studies. Since DNA replication is crucial to cell division, uncontrolled growth is a hallmark of tumors, S phase is a major target for chemo- and radiotherapy and errors in DNA replication lead to genomic instability, the relevance of this meeting to cancer research, and ultimately to improved therapies, cannot be overemphasized. Replication of DNA is a fundamental process in all (eukaryotic) life. This meeting will focus on understanding the mechanism by which this process occurs, and how DNA replication contributes to genome stability and maintenance of the epigenetic state of a cell. The intellectual merits of this conference include the opportunity for leading investigators at all stages of their scientific careers to share and discuss their latest results and concepts. The informal peer review in oral and poster sessions is invaluable in providing rapid feedback that will fruitfully steer and accelerate future research. This conference also provides ample opportunity for learning and building collaborations - no parallel sessions are planned and so all attendees share a common experience, while the secluded venue maximizes the likelihood of productive scientific exchange. Large conferences generally can have significant impact in their field. Unique aspects of this conference that have particularly broad impact are the active participation of younger scientists who will particularly benefit from the opportunity to present their latest ideas. The conference archive (Leading strand video archive accessible by the internet) allows participants to share aspects of the conference with their colleagues who were unable to attend while protecting the right of the presenting authors to present unpublished research.