OPTICAL BIOLOGY (SHARED RESOURCE)

光学技术的改进-激光应用，视频和共聚焦显微镜，细胞分选和分析，荧光探针的发展和定量，动态和时间分辨成像技术的发展-正在彻底改变细胞生物学，现在正在转化为临床医学的实践。光学生物学共享资源的主要目标是支持所有基础科学和临床研究项目，这些项目可以从光学方法的仪器和专业知识中受益。光学技术在诊断和治疗方面被广泛分类，相关的生物系统范围从亚细胞结构到组织。为了有效地利用独特的核心技术，共享资源被分为两个基本组成部分，服务和开发。该服务的组成部分已通过发展生物学中心，干细胞研究中心，实验室的遗传动力学（LFD）和新成立的复杂生物系统中心之间的伙伴关系扩展。通过与DEC和LFD合作任命新的设施经理（Michelle Digman博士）以及最近通过与CCBS合作购买新设备，开发组件（特别是诊断和基本亚细胞应用）得到了显着增强。通过与贝克曼激光研究所的持续合作，临床诊断和治疗的发展得到了大力加强。最近与免疫学中心的合作扩大了可用于细胞计数需求的仪器和专业知识。癌症中心成员的利益通过这些伙伴关系得到高度利用。技术指导、服务和支持由三个共享资源设施和人员提供，即OBC、BLI和细胞计数设施。共享资源主任和共同协调员就初始实验设计和匹配研究人员与适当的设施和合作者进行咨询。由于光学生物学背后的主要驱动力是新技术的发展，共享资源的第二个组成部分鼓励在基础科学和临床科学项目中开发和利用新的光学方法。这是由M. Digman和LFD或T. Krasieva和BLI。

Improvements in optical techniques - laser applications, video and confocal microscopy, cell sorting and analysis, the development of fluorescent probes and the development of quantitative, dynamic and time resolved imaging techniques- are revolutionizing cell biology and are now being translated into the practice of clinical medicine. The primary objective of the Optical Biology Shared Resource is to support all Basic Science and Clinical Research projects that can benefit from access to instrumentation and expertise in optical methods. Optical techniques are broadly classified in terms of diagnostics and therapeutics, and relevant biological systems range from sub cellular structures to tissues. To utilize the unique core technologies effectively, the Shared Resource has been divided into two fundamental components, Service and Development. The service component has been extended by partnerships between the Developmental Biology Center, the Stem Cell Research Center, the Laboratory for Fluoresence Dynamics (LFD) and the newly organized Center for Complex Biosystems. The development component especially for diagnostics and basic subcellular applications has been dramatically enhanced by the appointment of a new facility manager (Dr. Michelle Digman) in partnership with the DEC and LFD and by the recent acquisition of new equipment through a partnership with the CCBS. The development of clinical diagnostics and therapeutics is strongly enhanced through the continuing partnership with the Beckman Laser Institute. A recent partnership with the Center for Immunology has expanded the instrumentation and expertise available for cytometry needs. The benefits to Cancer Center members are highly leveraged through these partnerships. Technical instruction, service and support are provided by three Shared Resource facilities and personnel namely, the OBC, the BLI and the Cytometry facility. The Shared Resource Director and co-Coordinators consult on initial experimental design and matching investigators with the proper facility and collaborator. Since a primary driving force behind optical biology is the development of new technology, the second component of the Shared Resource encourages development and utilization of novel optical methods in the basic science and clinical science programs. This is fostered by collaborative efforts between M. Digman and the LFD or T. Krasieva and the BLI.