Core Center for Vision Research

继续寻求对密歇根大学视觉研究核心中心的支持。需要支助五个模块：1)设计和建造机械仪器的仪器车间模块，配备一名仪器制造商；2)电子和计算机模块，设计和制造电子设备，并协助研究计算机，配备一名电子工程师；3)形态和成像模块，用于处理眼组织的光学和电子显微镜、免疫组织化学和原位杂交，以及产生研究照片和数字图像，配备一名技术员；4)维维安姆模块，用于安置和护理用于视觉研究的实验室动物，配备一名兽医技术员；5)微阵列和分子生物学模块，为研究人员提供分子生物学所需的仪器和服务，以及处理和扫描商业基因芯片和定制微阵列载玻片，以研究眼组织中的基因表达，并配备一名技术人员。 密歇根大学视觉研究核心中心的具体目标是改善视觉科学家的研究环境，促进视觉系统及其疾病的合作研究，并扩大校园内的视觉研究，将非视觉科学家的技能和视角应用于视觉系统的研究问题。 参与调查的18名调查人员目前持有19笔NEI补助金。这些研究人员的研究兴趣广泛，包括电生理学、神经生物学、生物化学、分子生物学、分子遗传学、发育生物学、生物统计学、免疫学和临床眼科。 核心中心位于W.K.凯洛格眼科中心内，占地12万平方米。英国《金融时报》大楼内有专门用于每个模块的空间，以及最先进的基础和临床研究设施。

Continued support is sought for the Core Center for Vision Research at the University of Michigan. Support for five modules is requested: 1) an Instrument Shop Module for designing and constructing mechanical instrumentation, staffed by an instrument maker; 2) an Electronics and Computer Module for designing and constructing electronics equipment and assistance with research computers, staffed by an electronics engineer; 3) a Morphology and Imaging Module for the processing of ocular tissue for light and electron microscopy, immunohistochemistry and in situ hybridization, as well as the production of research photographs and digital images, staffed by a technician; 4) a Vivarium Module for the housing and care of laboratory animals used in vision research, staffed by a veterinary technician; and 5) a Microarray and Molecular Biology Module for providing investigators access to instrumentation and services necessary for molecular biology and the processing and scanning of commercial gene chips and custom microarray slides for the investigation of gene expression in ocular tissues, staffed by a technician. The specific aims of the Core Center for Vision Research at the University of Michigan are to enhance the research environment for vision scientists, facilitate collaborative studies of the visual system and its diseases, and expand vision research on this campus to bring the skills and perspectives of non-vision scientists to bear upon research issues of the visual system. The 18 participating investigators currently hold 19 NEI grants. The research interests of these investigators are diverse and include electrophysiology, neurobiology, biochemistry, molecular biology, molecular genetics, developmental biology, biostatistics, immunology, and clinical ophthalmology. The Core Center is housed within the W.K. Kellogg Eye Center, a 120,000 sq. ft. building containing space dedicated to each of the modules, plus state-of-the-art facilities for basic and clinical research.