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中文摘要
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描述(由申请人提供):威斯康星州的大学(UW)的计算和信息学在生物学和医学培训计划(CIBM)提出帮助培训下一代的计算科学家在健康和疾病研究。我们将扩大我们与马什菲尔德临床研究基金会之前的合作,也充分整合我们的计划与华盛顿大学的临床和转化研究所(ICTR)。计算和统计方法与生物医学科学之间的相互作用继续迅速扩大。计算机建模和信息学现在在生物学和医学中发挥着关键作用,我们的研究人员一直在开发用于分析分子和临床研究数据的新型最先进算法。参与CIBM的组织很强大。UW拥有每年10亿美元的外部资助研究组合,是一所领先的研究型大学。这项研究的很大一部分是在生物医学科学和相关领域,一些涉及CIBM的部门经常在各种民意调查中排名前十,包括计算机科学,遗传学,生物化学,统计学,化学和生物工程等。我们将继续加强这些优势,因为我们更多地转向健康和疾病相关的研究培训。CIBM的优势在于将计算机科学家、统计学家和信息学家的强大算法思维带到了存在挑战性问题的项目和领域。未来我们将继续使用这种模式。 我们在招聘和培养研究生和博士后研究员方面取得了巨大成功。我们在生物医学信息学领域产生的新教师数量,新的外部资助的多学科研究项目的发展以及我们参与少数民族招聘和安置证明了这一点。为了支持这些新的培训工作,我们在CIBM管理委员会中增加了新成员,包括UW ICTR临床研究信息学的新教员Eneida Mendonga教授和Marshfield诊所的牙科信息学家Amit Acharya博士。我们的课程现在包括与临床和转化研究密切相关的课程,我们建议包括博士后牙科信息学研究的新机会。该计划将很好地定位,为国家提供训练有素的生物医学信息学研究人员。
英文摘要
DESCRIPTION (provided by applicant): The University of Wisconsin's (UW) Computation and Informatics in Biology and Medicine Training Program (CIBM) is proposing to help train the next generation of computational scientists in health and disease research. We will extend our prior collaboration with the Marshfield Clinical Research Foundation to also fully integrate our program with UW's Institute for Clinical and Translational Research (ICTR). The interplay between computational and statistical methods and the biomedical sciences continues to expand rapidly. Both computer modeling and informatics now play a key role in both biology and medicine, and our researchers have been developing novel state-of-the-art algorithms for the analysis of molecular and clinical research data. The organizations involved in CIBM are strong. UW has a total externally funded research portfolio of $1B/year and is a leading research university. A good fraction of this research is in the biomedical sciences and related areas, and a number of departments involved in CIBM are regularly in the 'top ten' lists in various polls, including Computer Sciences, Genetics, Biochemistry, Statistics, Chemical and Biological Engineering, and others. We will continue to build on these strengths as we move more to health and disease-related research training. The strength of CIBM has been to bring strong algorithmic thinking from computer scientists, statisticians, and informaticists to projects and domains where challenging problems lie. We will continue to use this model going forward. We have demonstrated strong success in recruiting and training graduate students and postdoctoral fellows. This is evidenced by the number of new faculty we have produced in the biomedical informatics area, the development of new externally funded multi-disciplinary research projects, and our involvement in minority recruitment and placement. To buttress these new training endeavors we have added new members to our CIBM management committee, including Prof. Eneida Mendonga, a new faculty member in Clinical Research Informatics at UW's ICTR, and Dr. Amit Acharya, a dental informaticist from the Marshfield Clinic. Our curriculum now includes courses closely connected to clinical and translational research, and we propose to include new opportunities for postdoctoral dental informatics research. The program will be well positioned to serve the country with highly trained researchers in biomedical informatics.
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Linking Variants to Multi-scale Phenotypes via a Synthesis of Subnetwork Inference and Deep Learning
  • 批准号:
    10627971
  • 项目类别:
  • 资助金额:
    $65.56万
  • 财政年份:
    2021
  • 负责人:
    Mark W. Craven
  • 依托单位:
Linking Variants to Multi-scale Phenotypes via a Synthesis of Subnetwork Inference and Deep Learning
  • 批准号:
    10297205
  • 项目类别:
  • 资助金额:
    $32.46万
  • 财政年份:
    2021
  • 负责人:
    Mark W. Craven
  • 依托单位:
The Center for Predictive Computational Phenotyping-1 Overall
  • 批准号:
    9056632
  • 项目类别:
  • 资助金额:
    $269.23万
  • 财政年份:
    2014
  • 负责人:
    Mark W. Craven
  • 依托单位:
The Center for Predictive Computational Phenotyping-1 Overall
  • 批准号:
    9270103
  • 项目类别:
  • 资助金额:
    $29.76万
  • 财政年份:
    2014
  • 负责人:
    Mark W. Craven
  • 依托单位:
国内基金
海外基金
层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
  • 批准号:
    2021JJ40433
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2021
  • 负责人:
    孙磊
  • 依托单位:
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
  • 批准号:
    32001603
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2020
  • 负责人:
    段真珍
  • 依托单位:
AREA国际经济模型的移植.改进和应用
  • 批准号:
    18870435
  • 项目类别:
    面上项目
  • 资助金额:
    2.0万元
  • 批准年份:
    1988
  • 负责人:
    史树中
  • 依托单位: