Claude D. Pepper Older Americans Independence Centers (OAICS) (P30)

描述(由申请人提供)：这是密歇根大学(UM Pepper Center)克劳德·D·佩珀老年美国人独立中心(UM Pepper Center)的竞争性续签申请。密歇根大学胡椒中心的具体目标是：1)支持侧重于通过提高对影响衰老表型发展的预测和调节因素的了解来提高老年人独立性的研究，包括健康衰老和一系列残疾结果。2)通过支持将老年人老龄化和导致残疾的常见健康问题的基础研究与临床研究联系起来的翻译研究，帮助维持和恢复老年人的独立性。3)提供资源核心(RCS)，以支持和协助研究人员发起的研究项目，这些项目可以导致对导致衰老表型(包括共病和丧失独立性)的基本机制的新见解，并开发和测试应用于此类研究项目的创新方法。4)通过其研究职业发展核心(RCDC)，加强UM环境，以培训未来的学术带头人，他们将对导致老年表型的机制进行研究，并启动翻译研究，以提高老年人的独立性。5)通过其试点和探索性研究核心(PESC)，吸引密歇根大学初级教员(或以前没有参与老龄化研究的选定高级教员)研究易导致衰老表型的问题，并进行转化性研究，以减少残疾结果。密歇根州立大学胡椒中心，现正处于其持续的NIA资助的20“年，已经建立了良好的领导和管理结构，一个RCDC，一个PESC，和四个RCS：人类科目和评估核心；生物力学核心；方法学、数据管理和分析核心；以及老年啮齿动物核心设施。有突出的机构支持，包括密歇根州立大学承诺在拟议的5年续签期间支付近200万美元的直接费用。RCDC有三个核心要素：1)具有竞争力的计划，以选择有前途的UM初级教员提供工资支持，以开展与UM Pepper中心研究重点相关的研究；2)为从事此类研究的初级教员提供国家认可的研究培训计划；3)导师计划，增加初级教员与一名或多名UM高级研究人员密切合作的机会。PESC通过严格的外部审查，每年将资助5个或更多的试点项目。RCS将支持23个外部资助的项目、胡椒中心试点基金和RCDC初级教员，并继续开发和测试用于胡椒中心研究的新方法。

DESCRIPTION (provided by applicant): This is a competing renewal application for the Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center are: 1) To support research which has a focus on enhancing the independence of older adults by improved understanding of predictors and modulators influencing the development of aged phenotypes, including healthy aging and a range of disablement outcomes. 2) To help maintain and restore the independence of older people by supporting translational research linking basic with clinical research on aging and common health problems of older adults leading to disability. 3) To provide Resource Cores (RCs) to support and assist investigator initiated research projects which can lead to new insights into the basic mechanisms underlying conditions that contribute to aged phenotypes including comorbidity and loss of independence and which develop and test innovative methods to apply to such research projects. 4) Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders who will conduct research on mechanisms contributing to aged phenotypes, and initiate translational research to enhance independence of older adults. 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty (or selected senior faculty not previously involved in aging research) to study problems predisposing to aged phenotypes and to carry out translational research to reduce disablement outcomes. The UM Pepper Center, now in its 20"^ year of continuous NIA funding, has in place a well established leadership and administrative structure, an RCDC, a PESC, and four RCs: the Human Subjects and Assessment Core; the Biomechanics Core; the Methodology, Data Management and Analysis Core; and the Core Facility for Aged Rodents. There is outstanding institutional support, including a UM commitment of almost $2 million of direct costs over the proposed 5 years of this renewal. The RCDC features three central elements: 1) a competitive program to select promising UM junior faculty for salary support to conduct research relevant to the UM Pepper Center's research focus; 2) a nationally recognized research training program for junior faculty engaged in such research, and 3) a Mentorship Program that enhances opportunities for junior faculty members to work closely with one or more UM senior investigators. The PESC, through rigorous external review, will fund 5 or more pilot projects per year. The RCs will support 23 externally funded projects, the Pepper Center pilot grants and RCDC junior faculty, and continue to develop and test new methods to be used in Pepper Center research.