Malaria Vector Population Genetic Division and Vector Competence in Hainan Island

海南岛疟疾媒介种群遗传分化与媒介生存力 项目摘要 疟疾是一个严重的公共卫生问题，也是社会经济发展的障碍。 东南亚大湄公河次区域国家的发展。的巨大 该地区疟疾流行病学的地理异质性与不同的 对寄生虫具有不同媒介能力的媒介系统。作为主要措施， 疟疾控制战略、驱虫蚊帐和室内喷雾， 对拟除虫菊酯的抗药性，并极大地重塑了蚊子群落和种群结构。 在中国海南岛，广泛使用杀虫剂控制疟疾， 我国主要传疟媒介微小按蚊的锐减和近期回升 和东南亚不仅是由寄生虫驱动的病媒种群演替 重组了病媒群落，但复活的蚊子种群也显示出改变， 咬偏好基于这些观察，我们假设最近密集的疟疾 病媒控制措施和农业虫害控制措施造成了重大的 海南省传疟媒介生态物种演替与种群遗传瓶颈 中国的岛屿。因此，FIRCA提案旨在利用地理优势， 海南岛的分离，以阐明一种主要疟疾媒介的进化， 杀虫剂控制。我们将确定是否不同的生态型的一个。来自丘陵的极小 平原地区对恶性疟原虫感染的媒介能力不同。这 这项研究将提供宝贵资料，有助预测蚊子因应 东南部其他疟疾流行地区的灭蚊措施 亚洲拟议的研究将通过培养一名博士生来促进研究能力的建设。 学生和一名来自流行国家的博士后研究员。该项目将在 主要在中国重庆师范大学与陈斌博士合作，作为一名 NIH补助金U19 AI089672的延期。

Malaria Vector Population Genetic Division and Vector Competence in Hainan Island Project Summary Malaria is a significant public health problem and impediment to socioeconomic development in countries of the Greater Mekong Subregion of Southeast Asia. The tremendous geographical heterogeneity of malaria epidemiology in this region is associated with diverse vector systems with different vectorial capacities for the parasites. As the major measures of malaria control strategies, insecticide-treated bed nets and indoor sprays have resulted in pyrethroid resistance, and greatly reshaped the mosquito community and population structures. In Hainan Island of China, extensive use of insecticides for malaria control has led to an initially sharp decrease and recently rebound of Anopheles miminus, the key malaria vector in China and Southeast Asia. Not only has the insecticide-driven vector population succession restructured the vector community, but also the resurged mosquito population displayed altered biting preference. Based on these observations, we hypothesize that recent intensive malaria vector control measures and agricultural pest control measures have caused a significant ecological species succession and population genetic bottleneck of malaria vectors in Hainan Island, China. Therefore, this FIRCA proposal aims to take the advantage of geographical isolation of Hainan Island to elucidate the evolution of a major malaria vector in response to insecticide control. We will determine whether the different ecotypes of An. minimus from hilly and plain areas have different vectorial competence to Plasmodium falciparum infections. This study will provide invaluable information for the prediction of mosquito evolution in response to insecticides-based mosquito control measures in other malaria-endemic regions of Southeast Asia. The proposed research will contribute to building research capacity by training one Ph.D. student and one postdoc fellow from the endemic country. This project will be carried out primarily in China at Chongqing Normal University in collaboration with Dr. Bin Chen, as an extension of NIH grant U19 AI089672.