6th International Workshop on Seizure Prediction

描述(申请人提供)：这项工作的总体目标是召开第六届癫痫发作预测国际研讨会，这是一个论坛，汇集了一个国际跨学科小组，涉及癫痫专家、工程师、物理学家、数学家、神经外科医生和神经科学家，重点是开发癫痫治疗方法，特别是基于闭环预测和干预。虽然这一目标没有改变，但该小组已经认识到，关注的焦点需要从脑电和相关电生理学记录的无生物机制算法方法转移到更好地理解潜在的生理机制，因为它们特别与临床记录有关。在根本层面上，癫痫发作预测的目标是确定癫痫发作产生的潜在机制，并设计系统来检测这些动态并提供干预。本次会议将集中关注工程学、计算机学和癫痫神经科学相结合的基本问题，这些问题对于预测和干预癫痫发作是必要的：癫痫发作如何在新皮质发生，如何识别癫痫发作的起始点，癫痫发作如何扩散，以及如何终止。我们已将这些主题确定为在治疗耐药癫痫综合征方面取得进一步进展的关键障碍。通过这些问题，我们将重点关注临床和生理指标之间的桥梁，以达到理解癫痫发作发生机制的新方法，从神经元到生物体，特别是关闭癫痫发作发生模型和生理观察之间的循环。

DESCRIPTION (provided by applicant): The overall objective of this effort is to convene the Sixth International Workshop on Seizure Prediction, a forum that brings together an international interdisciplinary group involving epileptologists, engineers, physicists, mathematicians, neurosurgeons and neuroscientists focused on the development of treatments for epilepsy especially based on closed loop prediction and interventions. While this goal has not changed, the group has recognized that the focus of attention needs to shift away from a biological mechanism-free algorithmic approach to EEG and related electrophysiology recordings, and toward a better understanding of underlying physiological mechanisms as they specifically relate to clinical recordings. At a fundamental level, the goal of seizure prediction is to identif the underlying mechanisms of seizure generation and to engineer systems that will detect those dynamics and provide for intervention. This meeting will focus attention on basic questions at the intersection of engineering, computational and epilepsy neuroscience necessary for predicting and intervening with seizures: how seizures arise in the neocortex, how to identify sites of seizure origination, how seizures spread, and how they terminate. We have identified these topics as key roadblocks to further advances in treatment of pharmacoresistant epilepsy syndromes. Through these questions we will focus attention on bridging clinical and physiological metrics to arrive at new approaches to understand epileptic seizure generation mechanisms across all scales of brain from neuron to organism, and especially close the loop between models of seizure generation and physiological observations.