Short Course on Next-Generation Sequencing: Technology and Statistical Methods

描述(由申请人提供)：正在进行重大努力，以揭示许多复杂的人类疾病和数量性状的特定遗传成分。这些努力包括用于下一代测序的快速发展的技术，这将产生前所未有的丰富数据。这就需要进行复杂的统计分析，以便最大限度地利用从每项研究中收集到的信息。同样，在研究复杂遗传性状的统计方法方面也取得了许多进展，新的统计方法不断出台。为了加快和显著推进对易感这些复杂特征的特定基因的寻找，我们提出了一系列关于下一代测序技术和统计基因组学的年度短期课程，这将使更多的研究人员，包括临床研究人员，参与、贡献和领导此类研究。这些短期课程将帮助学生、博士后研究员、初级调查人员和高级调查人员加快基因组发现的速度。这些课程将由下一代测序和统计遗传学/基因组学方面的领先专家授课。每个为期4天的课程将提供下一代测序技术和与这些技术有关的统计方法方面的大量专业知识，这将有效地增加从事遗传和基因组研究的研究人员的数量和专业知识。这是一门独特的课程，包含下一代测序的技术和统计方面的指导。目前，美国还没有提供这种类型的课程。我们预计每门课程大约有50名学生参加，允许学生和教职员工进行密集的互动。课程将辅以广泛的讨论、讲义和样例演示。

DESCRIPTION (provided by applicant): Major efforts are under way to uncover the specific genetic components of many complex human disorders and quantitative traits. These efforts include rapidly evolving technologies for next- generation sequencing that will generate an unprecedented wealth of data. In that turn that will require sophisticated statistical analysis in order to maximize the information gleaned from each study. Likewise, many advances have been made in statistical methods for the study of complex genetic traits, and new statistical methods continue to be promulgated. To expedite and significantly advance the search for specific genes that predispose to these complex traits, we propose a series of annual short courses on next-generation sequencing technologies and statistical genomics which will enable a far greater number of researchers, including clinical researchers, to participate in, contribute to, and lead such research. These short courses will help equip students, post-doctoral fellows, junior investigators and senior investigators to expedite genomic discovery. The courses will be taught by leading experts in next-generation sequencing and statistical genetics/genomics. Each 4-day course will provide substantial expertise both in technologies for next- generation sequencing and in statistical methods pertaining to these technologies that will effectively increase the number and the expertise of investigators who are pursuing genetic and genomic research. This is a unique course containing instruction in both technological and statistical aspects of next-generation sequencing. There is currently no course of this type offered in US. We expect approximately 50 students to attend each course, allowing for intensive interaction between students and faculty. Lectures will be supplemented with extensive discussion sessions, handouts, and presentation of worked examples.