Center for Interdisciplinary Research on AIDS

描述（由申请人提供）：艾滋病跨学科研究中心（CIRA）成立于1997年，在抗逆转录病毒疗法出现之后，但在治疗作为预防的潜力建立之前。自成立以来，CIRA一直支持在国内和国际环境中进行各种跨学科研究，为艾滋病毒风险和传播的科学知识以及艾滋病毒干预措施在高度受影响的群体和环境中的成本效益和功效做出了重大贡献。在接下来的五年里，CIRA将专注于激励和支持创新的跨学科研究，结合行为，社会和生物医学方法，重点是实施艾滋病毒预防和治疗以及消除艾滋病毒差异。我们将利用我们的科学家和合作伙伴的广泛和多学科的专业知识，通过背景化的实施科学和持续支持跨学科的艾滋病毒研究教育和培训计划，对全球流行病产生更大的影响，这些计划将使艾滋病毒研究领域多样化并得到补充。在艾滋病毒科学最新进展的基础上，该中心将促进和支持战略领域的各种研究计划，重点是实施/翻译研究和组合，多层次的方法。作为新英格兰唯一的艾滋病预防研究中心，我们将建立一个艾滋病毒研究人员和服务提供者的区域网络，重点是在艾滋病毒感染率高的小城市中心进行实施研究，例如，普罗维登斯和纽黑文，这一独特的举措将通过支持制定和实施针对艾滋病毒高流行率的小城市的有效艾滋病毒干预措施，补充目前为解决12个最大都市地区国家艾滋病毒/艾滋病战略执行差距所作的努力。我们的全球研究还将侧重于在资源匮乏的环境中推进实施科学和具有成本效益的可持续艾滋病毒干预措施，特别是南非，俄罗斯和中国。CIRA的新使命将通过五个核心的协调努力来实施：行政，发展，社区研究和实施，临床卫生服务研究和跨学科研究方法，与我们的战略重点保持一致，每个核心将在支持实施科学和建设能力方面发挥作用，以便在艾滋病毒流行率高的小城市中心进行研究。在新的项目期间，解决与开展艾滋病毒研究有关的法律、政策和道德问题也将是CIRA及其核心工作的组成部分。将通过系统的监测和评价来衡量核心一级和整个中心的影响。

DESCRIPTION (provided by applicant): The Center for Interdisciplinary Research on AIDS (CIRA) was founded in 1997, after the emergence of antiretroviral therapy but before the potential of treatment as prevention had been established. Since its inception, CIRA has supported a diverse portfolio of interdisciplinary research in domestic and international settings,contributing significantly to scientific knowledge of HIV risk and transmission and the cost-effectiveness and efficacy of HIV interventions in highly impacted groups and settings. In the next five years CIRA will focus on stimulating and supporting innovative interdisciplinary research that combines behavioral, social and biomedical approaches, focused on the implementation of HIV prevention and treatment and the elimination of HIV disparities. We will leverage the extensive and multi-disciplinary expertise of our scientists and partners to have a greater impact on the global epidemic through contextualized implementation science and ongoing support of interdisciplinary HIV research education and training programs that will diversify and replenish the field of HIV research. Building on recent advances in HIV science, the Center will foster and support various research programs in strategic areas with emphasis on implementation/translation research and combination, multi-level approaches. As the sole AIDS Prevention Research Center in New England, we will create a regional network of HIV researchers and service providers focused on the conduct of implementation research in small urban centers with high HIV infection rates, e.g., Providence and New Haven, This unique initiative will complement ongoing efforts to address implementation gaps in the National HIV/AIDS Strategy in the 12 largest metropolitan areas by supporting the development and implementation of effective HIV interventions tailored to smaller cities with high HIV prevalence. Our global research will also focus on advancing implementation science and cost-effective, sustainable HIV interventions in low resource settings, particularly South Africa, Russia and China. CIRA's new mission will be implemented through the coordinated effort of five Cores: Administrative, Development, Community Research and Implementation, Clinical Health Services Research, and Interdisciplinary Research Methods, In keeping with our strategic foci, each Core will have a role in supporting implementation science and building capacity to conduct research in small urban centers with high HIV prevalence. Addressing law, policy and ethics issues related to the conduct of HIV research will also be integral to the work of CIRA and its Cores in the new project period. Core level and center-wide impact will be measured through systematic monitoring and evaluation.