Photograph Reading Center for the Comparison of AMD Treatments Trial

描述（由申请人提供）：AMD治疗比较试验（CATT）是一项多中心，随机临床试验，研究Lucentis和Avastin治疗新生血管性AMD。本基金照片阅读中心（FPRC）申请中提出的活动的主要目标是为CATT提供支持。这一支持包括A)评估随访眼底照片，以评估两种治疗后脉络膜新生血管的变化和视网膜血管直径的变化；B)评估这些发现与CATT OCT阅读中心发现的相关性。这项持续拨款提案有两个具体目标：目标1，在所有参与者中完成对原始CATT拨款申请的为期两年的跟进。由于CATT试验的患者入组被推迟，完成两年随访所需的时间必须延长，超出原计划中提出的时间。目的2：进行一项为期3年的观察性研究，以调查研究药物的长期影响。在整个拟议的研究中，FPRC将为CATT提供可靠、及时、可重复和系统的彩色照片和血管造影图像材料分级。这些活动将与CATT研究的头几年提供的活动类似。FPRC还将继续为读者、摄影师、诊所协调员和眼科医生的认证和培训实施研究特定的材料和方法。FPRC的活动也将支持研究目标，作为招聘、研究小组会议、演讲和出版物的形象资源。相关性（见说明）：在美国和大多数西方国家，年龄相关性黄斑变性（AMD）是导致失明的主要原因。这些关于这两种药物的相对有效性和安全性的研究将决定未来如何治疗新生血管性AMD患者。

DESCRIPTION (provided by applicant): The Comparison of AMD Treatments Trial (CATT) is a multi-center, randomized clinical trial investigating the treatment of neovascular AMD with Lucentis and Avastin. The primary objective of the activities proposed in this fundus Photograph Reading Center (FPRC) application is to provide support to the CATT. This support includes A) the evaluation of follow-up visit fundus photographs to assess the changes in the choroidal neovascularization and the changes in retinal vessel diameters following both treatments; and B) assessment of the correlation of these findings with the findings of the CATT OCT Reading Center. This continuation grant proposal has two Specific Aims: Aim 1, to complete in all participants the two-year follow up of the original CATT grant application. Because enrolment of patients in the CATT trial was delayed, the period needed to complete the two year follow up must be extended beyond the time period proposed in the original plan. Aim 2, to perform an observational study for an additional 3-year follow up to investigate the long term effects of the study medications. Throughout the proposed studies the FPRC will provide reliable, timely, reproducible, and systematic grading of submitted color photographs and angiographic image materials for CATT. These activities will be similar to those provided in the first years of the CATT study. The FPRC will also continue to implement study specific materials and methods for reader, photographer, clinic coordinator, and ophthalmologist certification and training. FPRC activities will also support study goals as an image resource for recruitment, Study Group meetings, presentations and publications. RELEVANCE (See instructions): Age-related macular degeneration (AMD) is the leading cause of blindness in the United States and most western countries. These studies of the relative effectiveness and safety of the two drugs under study will determine how patients with neovascular ("wet") AMD are treated in the future.