Mood Disorders Clincal Intervention Training Program

描述（由申请人提供）：此拨款申请用于更新T32培训计划，旨在帮助满足对熟练的情绪障碍临床干预研究人员的需求。本申请要求支持为期三年的博士后培训计划（每年2名研究员），在整个生命周期（青少年，成人，老年）的情绪障碍（双相或单相障碍）的临床干预研究。该项目面向完成成人住院医师要求的精神科医生或获得博士学位的临床心理学家。该项目有三个组成部分：包括教学和研讨会形式的核心课程，三个需要监督的临床研究轮转，包括患有双相情感障碍或单相情感障碍的青少年或成人患者。这种多年的指导经验旨在帮助学员制定和实施第三个组成部分，即独立的临床研究项目，这将导致申请独立的研究经费。该系在共同开展研究和培训新的临床研究人员方面有多年的经验。核心培训教师在一系列干预措施的研究中建立了良好的记录，包括ECT，认知疗法，金丝桃，抗抑郁药物，运动以及药物和心理治疗的结合。他们在进行早期开放标签试验、单点和多点随机试验以及在所有年龄的患者中进行疗效和有效性试验方面也有经验。在与一般医学、认知和药物滥用障碍相关的情绪障碍的干预研究中，可获得研究培训经验（基于同伴愿望）。此外，这次培训还将提供一个独特的机会，与大型多中心试验网络、我们新的先进成像中心和其他转化研究机会一起工作。该计划将提供一个正式的培训计划，并提供可预测的支持，并将为受训者提供正确开展临床干预研究、伦理、人类受试者问题、同意程序、症状、功能、生活质量和医疗保健成本的临床测量，以及研究设计、统计分析方法、同行评审文章和研究经费申请的准备方面的知识和经验。

DESCRIPTION (provided by applicant): This grant application is for the renewal of a T32 training program designed to help meet the need for skilled clinical intervention researchers in mood disorders. This application requests support for a three-year postdoctoral training program (2 fellows per year) in clinical intervention studies in mood disorders (either bipolar or unipolar disorders) across the lifespan (juvenile, adult, geriatric). The program is open to psychiatrists who have completed adult residency requirements or clinical psychologists who have been awarded their Ph.D. The program has three components: a core curriculum including didactic and workshop formats, three required supervised clinical research rotations that includes juvenile or adult patients with either bipolar or unipolar disorders. This mentored multiyear experience is designed to assist trainees in developing and implementing the third component, an independent clinical research project, which will lead to an application for independent research funding. This faculty has many years of experience in conducting research together and in training new clinical researchers. The core training faculty has established track records in the study of a wide array of interventions including ECT, cognitive therapy, hypericum, antidepressant medications, exercise, and the combination of medications and psychotherapy. They are also experienced in the conduct of early open label trials, single and multi site randomized trials, as well as in conducting efficacy and effectiveness trials in patients of all ages. Research training experiences are available (based on fellow desire) in intervention research in mood disorders associated with general medical, cognitive, and substance abuse disorders. In addition, this training will also provide a unique opportunity to work with large multi center trial networks, our new advanced imaging center and other translational research opportunities. This program will provide a formal training program with predictable support, and will provide trainees with knowledge and experience in the proper conduct of clinical intervention research, ethics, human subjects issues, consent procedures, clinical measurement of symptoms, function, quality of life, and healthcare costs, as well as research design, statistical analytic approaches, and preparation of peer-reviewed articles and research grant applications.