Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women

西班牙裔和西班牙裔之间的乳腺癌发病率相差两倍以上。 非西班牙裔白人(Nhw)妇女；西班牙裔妇女确诊后存活率较低 而不是新的女人。我们建议评估乳腺癌患者的这些健康差异。 美国印第安人到NHW妇女沿途的发展和生存 利用四角州、加利福尼亚州和墨西哥城的现有资源。 利用的现有资源将是行为和社会生活方式暴露数据，以及 在面谈时获得的DNA。生存数据一直在进行，并将继续下去 通过当地的SEER和CDC肿瘤登记处进行监测。基因和生活方式数据是 从大约8039例西班牙裔和NHW乳腺癌病例中获得 以人口为基础的控制。通过汇集三项研究的资源，我们将有效地 研究一条我们认为对乳腺癌发展很重要的生物途径 和生存率，这影响了西班牙裔和西班牙裔之间乳腺癌发病率的差异 不好的女人。对遗传因素的评估将集中在一条似乎有效的途径上 与胰岛素、雌激素和炎症相关的通路和 表示一个汇聚点。这条路径，我们称之为汇聚 激素、炎症和能量功能(首席)信号通路 没有在西班牙裔或非西班牙裔白人女性中进行全面研究， 将包括待研究的烯包括SOC1、SOC2、AKT、FRAP1(别名mTOR)、P13K、 STK11、AMP、PTEN、VEGF、&S6K1、S6K2、CRP、NFKB、IKB、IL10、IL8、IL6、TNFpha 使用Illumina平台。将测试乳腺癌与基因之间的关联 西班牙裔和nhw妇女以及 美国印第安人后裔的比例。信号通路基因与细胞因子的相互作用 与非甾体抗炎药、阿司匹林、体重指数、雌激素和体力活动 检查过了。这些遗传因素将通过存活来评估，以确定它们的 观察到西班牙裔和nhw妇女存活率差异的贡献。

The incidence rates of breast cancer vary more than two-fold between Hispanic and non-Hispanic white (NHW) women; Hispanic women have worse survival after diagnosis than NHW women. We propose to evaluate these health disparities in breast cancer development and surival along the continuation of American Indian to NHW women utilizing existing resources from the 4 Corner's States, California, and Mexico City. Existing resources utilized will be behorial and social lifestyle exposure data along with DNA obtained at the time of interview. Survival data has been ongoing and will continue to be monitored via local SEER and CDC tumor registries. Genetic and lifestyle data are available from approximately 8039 Hispanic and NHW cases of breast cancer and population-based controls. By pooling resources from three studies, we will efficiently examine a biological pathway that we believe is important to breast cancer development and survival and that influences differences in breast cancer rates among Hispanic and NHW women. Evaluation of genetic factors will focus on a pathway that appears to work in conjunction with insulin-, estrogen-, and inflammation-related pathways and represents a point of convergence. This pathway, which we call the Convergence of Hormones, Inflammation, and Energy Functioning (CHIEF) Signaling Pathway has not been studied comprehensively in either Hispanic or non-Hispanic white women and will include enes to be studied include SOC1, SOC2, AKT, FRAP1(alias mTOR), P13K, STK11, AMP, PTEN, VEGF, & S6K1,S6K2, CRP, NFKB, IKB, IL10, IL8, IL6, TNFalpha using an Illumina platform. Breast cancer associations will be tested between genetic polymorphisms and haplotypes of these genes in Hispanic and NHW women and by proportion of American Indian ancestry. Interaction of signaling pathway genes with each other and with NSAIDs, aspirin, BMI, estrogen, and physical activity will be examined. These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women.