IHVN H3 Africa Biorepository Initiative

描述（申请人提供）：非洲微生物组和基因组研究合作中心（ACCME）尼日利亚人类病毒学研究所（IHVN）由非洲科学家Clement Adebamowo博士领导，他曾担任非洲I期HapMap项目的首席研究员，不仅是非洲大陆基因组研究的先驱领导者，也是解决基因组伦理挑战的先驱领导者。研究大陆。ACCME生物储存库由Alash'le Abimiku博士领导，他是一位经验丰富的非洲实验室科学家，在非洲拥有20年的研究和储存经验，也是本提案的主要研究员。第一阶段实施的目标是：提高ACCME生物储存库的能力，以实现第二阶段实施所需的国际生物与环境储存库协会（ISBER）最佳实践。为了实现第一阶段的目标，ACCME生物储存库与Coriell研究所合作实施三个具体目标：1）评估当前实践并确定优势和差距; 2）升级储存库实践和基础设施; 3）进行试点第二阶段实施。这一为期两年的第一阶段进程涉及IHVN经验丰富的非洲科学家和技术人员与Coriell研究所的同行之间基于质量评估的迭代互动，后者提供客观评估，互动教学和指导能力建设，以灌输ISBER最佳实践为第二阶段实施借鉴Coriell经过验证的模型。第二阶段的目标是：扩大ACCME生物储存库的能力，以支持多个H3 Africa研究人员在非洲进行高质量的基因组学和转化研究，使用H3 Africa和更大的研究社区可以获得的经过良好处理，保存和质量控制以及冗余保护的人类生物样本。为了实现第二阶段的5年目标，ACCME生物储存库有5个具体目标：1）实施一个高质量的原始人类生物样本生物储存库; 2）开发、实施、管理和支持基于云计算的强大生物信息学工具，以支持生物储存库的能力; 3）建立行政管理和质量保证/质量控制（QA/QC）程序以及可持续的资金战略; 4）对工作人员进行生物储存和生物库科学方面的短期、中期和长期培训和指导; 5）整合生物库和生物储存伦理方面的最佳实践。这一五年计划分阶段扩大工作人员和基础设施，以支持非洲多个基因组研究伙伴，具体做法是提供可靠的样本处理支持、安全的运输、样本质量的快速登记和记录、关于临床和流行病学数据以及样本数量和质量的可获取信息、可靠的检索和积极促进合作，以实现最佳科学和可持续做法及供资。持续的质量改进，以实现可靠的存储库功能，并从最终用户那里获得持续的反馈，从而促进了对服务交付和产品质量的信任。 公共卫生相关性：该提议以现有的生物储藏库为基础，支持H3非洲联合会和非洲科学家网络研究常见疾病的基因组学和环境决定因素，以改善非洲人口的健康。由于人类起源于非洲并迁移到世界各地，因此对非洲人民的基因研究是促进全球人类健康的有力战略。设在非洲的生物库对于促进非洲科学家和更广泛的研究界的这一研究非常重要。

DESCRIPTION (provided by applicant): The African Collaborative Center for Microbiome and Genomics Research (ACCME), based at the Institute of Human Virology-Nigeria (IHVN) is led by Dr. Clement Adebamowo the African scientist who served as the Principal Investigator of the African Phase I HapMap Project and is a pioneering leader not only in genomic research on the African Continent but also in addressing the ethical challenges of genomic research on the Continent. The ACCME Biorepository is directed by Dr. Alash'le Abimiku, a highly experienced African laboratory scientist with two decades of research and repository experience in Africa, and the Principal Investigator of the current proposal. The goal of Phase I implementation is to: Advance the capacity of the ACCME Biorepository to achieve International Society for Biological and Environmental Repositories (ISBER) best practices required for Phase II implementation. To achieve the Phase I goal the ACCME Biorepository partners with the Coriell Institute to implement three Specific Aims: 1) Assessment of current practice and identify strengths and gaps; 2) Upgrade repository practice and infrastructure; 3) Conduct pilot Phase II implementation. This two-year Phase I process engages an iterative quality assessment-based interaction between experienced African scientists and technicians at IHVN and their counterparts from Coriell Institute who provide objective assessment, interactive didactic and mentored capacity building to instill ISBER best practices for Phase II implementation drawing upon Coriell proven models. The goal of Phase II is to: Expand the capacity of the ACCME Biorepository to support multiple H3Africa investigators to conduct high quality genomics and translational research in Africa using well processed, preserved and quality controlled and redundantly protected human biological samples accessible to the H3Africa and larger research community. To achieve the 5-year Phase II goals the ACCME Biorepository targets 5 Specific Aims: 1) Implement a high quality biorepository of primary human biologic samples; 2) Develop, implement, manage and support robust cloud computing based bioinformatics tool to support biorepository capacity; 3) Establish administrative governance and Quality Assurance/Quality Control (QA/QC) procedures and sustainable funding strategies; 4) Conduct short, medium and long term training and mentoring of staff on Biorepository and Biobanking Sciences; 5) Integrate best practices in biobanking and biorepository ethics. This 5-year plan implements a staged expansion of staffing and infrastructure to support multiple African genomic research partners by providing reliable sample processing support, secure shipping, rapid accession and documentation of sample quality, accessible information on clinical and epidemiological data and sample quantity and quality, reliable retrieval and proactive facilitation of collaboration to achieve best science and sustainable practice and funding. Continuous quality improvement for reliable repository function and ongoing feedback from end users fosters trust in service delivery and product quality. PUBLIC HEALTH RELEVANCE: This proposal builds on an existing biorepository to support the H3Africa Consortium and networks of African scientists to study genomics and environmental determinants of common diseases with the goal of improving the health of African populations. Since the human race originated in Africa and migrated to populate the world, studies of genes in African peoples are a powerful strategy for advancing human health globally. A biorepository based in Africa is important to promoting this research by African scientists and the broader research community.