Hazardous Waste Risk and Remediation in the Southwest

描述（由申请人提供）：亚利桑那大学超级基金基础研究计划（UA SBRP）更新申请的实质是美国西南部的危险废物风险和补救。该计划的主题是通过毒理学和水文地质学研究以及创新的补救技术，支持金属和有机污染物风险评估过程的发展。我们的申请强调了西南部（和墨西哥边境）与环境独特干旱性质相关的危险废物问题。重要的是，这些研究的结果可以外推到世界各地的干旱环境。目前，1/3的陆地表面是干旱或半干旱的，由于气候变化，这一比例预计将增加。我们研究的有毒物质、金属（砷）和卤化烃就是一个例子，它们是我们区域的主要污染物，但也是全世界严重关切的问题。我们的计划包括9个研究项目-五个生物医学项目和四个环境科学项目。许多项目都是涉及多个学科的合作项目。这些生物医学项目正在研究砷在靶组织中的毒性机制、影响人群对砷引起的毒性敏感性的因素以及潜在的治疗方法。环境科学项目正在研究如何对危险废物（砷、三氯乙烯/四氯乙烯）进行最佳表征，以进行风险评估和补救，并开发创新技术，以评估我们干旱的西南环境中的暴露和废物控制。这些研究项目得到五个核心的支持：管理该计划，将结果转化为利益相关者，提供研究服务，促进对沿着边境少数民族社区的独特外联工作，并支持研究生培训。该项目将有助于我们了解毒理学和国内和国际危险废物的补救。

DESCRIPTION (provided by applicant): The essence of the University of Arizona Superfund Basic Research Program (UA SBRP) renewal application is hazardous waste risk and remediation In the US Southwest. The theme of this Program Is to support development of a risk assessment process for metal and organic contaminants through toxicologic and hydrogeologic studies and innovative remediation technologies. Our application emphasizes hazardous waste issues in the Southwest (and Mexican Border) associated with the distinctive arid nature of the environment. Importantly, the outcomes of these studies can be extrapolated to arid environments around the world. Currently 1/3 of land surfaces are arid or semi arid and this proportion is expected to increase due to climate change. This is exemplified by the toxicants we study, metals (arsenic) and halogenated hydrocarbons, which are major contaminants in our region but also of significant concern throughout the world. Our Program consists of 9 research projects - five biomedical projects and four environmental sciences projects. Many of the projects are collaborative involving multiple disciplines. The biomedical projects are examining the mechanism of arsenic toxicity in target tissues, factors that affect the susceptibility of populations to arsenic-induced toxicity, and potential therapeutic approaches. The environmental sciences projects are investigating how hazardous wastes (arsenic, TCE/PCE) can be optimally characterized for risk assessment and remediation, and developing innovative techniques for assessing exposure and waste containment in our arid Southwest environment. These research projects are supported by five Cores that: administer the Program, translate the results to stakeholders, provide research services, promote unique outreach efforts to ethnic communities along the Border, and support graduate student training. This project will contribute to our understanding of toxicology and remediation of hazardous wastes nationally and internationally.