Etiological Studies of Gastric Carcinoma

描述(由申请者提供)：该计划项目的总体目标是利用哥伦比亚独特的人口实验室来促进我们对胃癌病因的理解。该计划项目在路易斯安那州立大学工作了22年，但2005年的卡特里娜飓风严重扰乱了该机构的活动。从那时起，业务基地转移到田纳西州纳什维尔的范德比尔特大学。这一转移对研究非常有益，因为哥伦比亚独特的实地工作机会现在被一个扩大的科学家团队利用，他们的重点是幽门螺杆菌感染。哥伦比亚的实地工作继续不间断地进行高效和经济的运作。提出了三个项目和三个核心。项目1建议继续对先前接受幽门螺杆菌感染治疗的成人和儿童队列进行长期跟踪。它还建议利用多年来积累的组织库来研究进展的生物标记物，特别是DNA甲基化。项目2解决了寄生虫对幽门螺杆菌感染反应的免疫调节问题，在人类和实验动物中。项目3研究了从低风险人群和高危人群中分离的幽门螺杆菌诱导的氧化应激。核心A为所有项目提供组织病理学服务。核心B处理所有行政事务和数据管理。核心C协调在哥伦比亚的所有实地工作。

DESCRIPTION (provided by applicant): The overarching goal of this Program Project is to advance our understanding of gastric cancer causation utilizing the unique population laboratory identified in Colombia. This Program Project was based at Louisiana State University for 22 years but the activities at that institution were seriously disrupted by Hurricane Katrina in 2005. Since then, the base of operations was transferred to Vanderbilt University in Nashville, TN. This transfer has been highly beneficial for the research because the unique field work opportunities in Colombia are now exploited by an expanded team of scientists whose focus has been Helicobacter pylori infection. The field work in Colombia has continued its highly efficient and economical operation uninterrupted. Three projects and three cores are proposed. Project 1 proposes to continue the long-term follow up of cohorts of adults and children previously treated for Helicobacter pylori infections. It also proposes to study biomarkers of progression, especially DNA methylation, utilizing the tissue bank accumulated over the years. Project 2 addresses the issue of immune modulation by parasites of the response to H. pylori infection, in humans and experimental animals. Project 3 studies oxidative stress induced by Helicobacter isolated from low and high risk populations. Core A provides histopathology services for all projects. Core B deals with all administrative matters and data management. Core C coordinates all field work in Colombia.