Predoctoral Training Program in Genetics

描述（由申请人提供）：该提案旨在为耶鲁大学跨部门遗传学培训计划（TPG）内的博士前培训提供持续的NIH支持。2010-2011年，有30 TPG研究生，其中14（在1年至3）目前由美国国立卫生研究院在遗传学博士前培训补助金的支持。该计划由两名共同主任，克莉丝汀雅各布-瓦格纳和瓦莱丽Reinke，以及代表耶鲁大学遗传学研究界的横截面的7名教师组成的执行委员会监督。来自艺术与科学学院（FAS）和耶鲁医学院的73名教师作为培训师参与了该计划。主要的行政和培训实体在三个部门：遗传学系在耶鲁大学医学院和分子，细胞和发育生物学（MCDB）和生态学和进化生物学（EEB）在FAS部门。该计划提供现代遗传学各个方面的培训，包括临床遗传学，DNA修复和癌症遗传学，基因组学和生物信息学，微生物遗传学，发育遗传学，免疫遗传学以及进化和群体遗传学。所有被录取的学生都至少拥有相关领域的学士学位，并通过申请进入耶鲁大学生物和生物医学科学（BBS）部门间课程或EEB课程。该方案有两个主要改进。从2012年秋季开始，学生将在第一年获得耶鲁大学的全面机构支持（助学金，学费和健康福利），其中包括正式的课程工作和三个研究轮换。现已设计了一门现代遗传学和基因组分析的新课程，重点是定量方法，现已在春季学期开课。在第一年结束时，学生从参与TPG教师的池中选择一名博士生导师。第二年包括密集的研究，课程工作和资格考试，其中包括书面和口头部分。遗传学培训计划还包括学生组织的年度研讨会，内部研究进展研讨会系列和各种研讨会。所有学生都经历了至少一年的监督教学，并获得旅行资金，参加并在国家或国际科学会议上展示他们的工作。所有TPG学生都由TPG董事指导，除了他们的论文委员会。大多数毕业生继续在学术和研究机构或生物技术和制药公司担任领导职务。考虑到第一年新的机构支持，我们的申请人的质量和深度，以及我们目前在遗传学培训的优势，我们要求资金支持16名研究生在第二年至第三年的五年期。

DESCRIPTION (provided by applicant): This proposal is for continued NIH support for predoctoral training within the interdepartmental Training Program in Genetics (TPG) of Yale University. For 2010-2011, there are 30 TPG graduate students, of which 14 (in years 1 to 3) are currently supported by the NIH predoctoral training grant in Genetics. The program is overseen by two co-Directors, Christine Jacobs- Wagner and Valerie Reinke, and an executive committee of 7 faculty members representing a cross-section of the genetics research community at Yale. Seventy-three faculty from departments of the Faculty of Arts and Sciences (FAS) and the Yale Medical School are involved in the program as trainers. The principal administrative and training entities are within three departments: the department of Genetics at the Yale Medical School and the departments of Molecular, Cellular and Developmental Biology (MCDB) and Ecology and Evolutionary Biology (EEB) in the FAS. The program offers training in all aspects of modern genetics, including clinical genetics, DNA repair and cancer genetics, genomics and bioinformatics, microbial genetics, developmental genetics, immunogenetics, and evolutionary and population genetics. All students admitted to the program have at least a Bachelor's degree in a relevant field and enter via application to the Yale interdepartmental program in Biological and Biomedical Sciences (BBS) or to the EEB program. Two major improvements have been made to the program. Starting Fall 2012, the students will receive full institutional support (stipend, tuition and health benefits) from Yale during their first year, whih includes formal course work and three research rotations. A new course in modern genetic and genome analysis, with emphasis on quantitative methods, has been designed and is now available during the spring semester. At the end of year 1, students select a doctoral advisor from the pool of participating TPG faculty. Year 2 consists of intensive research, course work, and the qualifying examination, which has written and oral components. The Training Program in Genetics also features a student-organized annual symposium, an in-house research-in-progress seminar series, and various workshops. All students experience at least one-year of supervised teaching and receive travel funds to attend and present their work at national or international scientific meetings. All TPG students are mentored by the TPG directors, in addition to their thesis committee. The majority of graduates go on to leading positions in academic and research institutions or in biotechnology and pharmaceutical companies. Given the new institutional support for the first year, the quality and depth of our pool of applicants, and the strengths of our current training in Genetics, we request funds to support 16 graduate students in years 2 to 3 for a five-year period.