Integrated photoacoustic and ultrasound imaging with the Vevo LAZR

描述(由申请人提供)：这份赠款申请是购买Vevo(R)LAZR扫描仪的申请，用于高分辨率、实时的3D光声和超声成像。该扫描仪将是宾夕法尼亚大学(UPenn)小动物成像设施(SAIF)的一部分，并将作为校园内不同部门的调查人员共享的资源。费城地区是基础和转化性生物医学研究的大量一流机构的所在地。我们将推广这一工具，并将其提供给费城地区的其他机构。Vevo(R)LAZR是一种最先进的双模式扫描仪，集成了光声学和高频超声波。它将光学成像的灵敏度与超声波的分辨率和深度穿透结合在一起。它是一个单一平台，具有多种应用，包括传统模式，如扫描和多普勒成像，以及更高级的应用，如弹性成像、微血管成像、血氧饱和度和血红蛋白测量。这一多功能仪器将支持大约20项研究提案。它的运作将由一支经验丰富的团队管理，该团队在动物和成像研究方面有着良好的记录。为Vevo(R)LAZR提供的资金支持将在开发新的诊断测试和治疗干预措施方面进一步进行转化研究，以满足传统和紧急需求。宾夕法尼亚大学和该地区其他机构广泛的研究界可以使用这种独特的扫描仪，这将促进研究小组之间的跨学科互动，并促进研究和教育的整合。简而言之，Vevo(R)的上市 LAZR将对宾夕法尼亚大学正在进行的和未来的生物医学研究产生重大影响。

DESCRIPTION (provided by applicant): This grant application is a request to purchase a Vevo(R) LAZR scanner for high-resolution, real-time 3D photoacoustic and ultrasound imaging. The scanner will be a part of the Small Animal Imaging Facility (SAIF) at the University of Pennsylvania (UPenn) and will be used as a shared resource by investigators from different departments across campus. The Philadelphia region is home to a large number of premier institutions of basic and translational biomedical research. We will promote the instrument and make it available to other institutions in the Philadelphia area. The Vevo(R) LAZR is a state-of-the-art dual-modality scanner that integrates photoacoustics and high- frequency ultrasound. It combines the sensitivity of optical imaging with the resolution and depth penetration of ultrasound. It is a single platform with multiple applications that include traditional modes like -scan and Doppler imaging along with more advanced applications like elasticity imaging, microvascular imaging, and oxygen saturation and hemoglobin measurements. The versatile instrument will support approximately twenty research proposals. Its operation will be managed by an experienced team with an established track record in animal and imaging research. Funding support for the Vevo(R) LAZR will further translational research in developing new diagnostic tests and therapeutic interventions for traditional and emergent needs. Access to this unique scanner for the wide research community at the University of Pennsylvania and other institutions in the region will promote interdisciplinary interactions between research groups, as well as facilitate the integration of research and education. In short, availability of the Vevo(R) LAZR will have a significant impact on ongoing and future biomedical research at the University of Pennsylvania.