Environmental Epidemiology, Statistics and Informatics Facility Core (EESIFC)

项目总结/摘要 西奈山伊坎医学院寻求形成一个新的环境健康科学核心 西奈山跨学科中心对早期环境暴露的健康影响。我们 中心将利用西奈山的显着最近的增长，并建立在我们的国内和国际 儿童环境健康方面的知名项目。 我们中心的使命是了解生命早期的环境暴露如何影响健康， 发展，以及整个生命周期中的疾病和功能障碍风险-婴儿期，儿童期，青少年期 以及更远的地方我们将研究化学、遗传、营养和社会暴露对健康的影响， 他们之间的互动。我们的方法将是跨学科和高度翻译。我们将联合收割机 临床，人口为基础的和生物学研究与领先的遗传学，表观遗传学和生物信息学 in the setting设置of a hospital医院based基础，urban城市school学校of medicine医.通过我们的临床和社区合作伙伴关系， 我们会将研究成果转化为循证的疾病预防和治疗方法。 为了加强研究，本中心将设立三个研究小组：内分泌和代谢 干扰，神经免疫调节和氧化剂-抗氧化剂失衡。这些研究小组将带来 基础科学家、临床医生和人口科学家一起致力于开发新的、跨学科的 环境卫生研究研究小组将得到三个设施核心的支持： 综合健康科学设施核心与暴露生物标志物，分子生物标志物， 临床人群访问和胎盘生物库;环境流行病学，统计学和 信息学设施核心;和一个面向临床的表型和压力评估设施核心。的 中心支持试点项目计划，职业发展计划和社区外展， Engagement Core致力于与多元化和多元化的企业进行双向沟通和合作， 西奈山服务的弱势群体。 西奈山吸引了资金雄厚的高级教师谁将在我们的中心领导人，建立了一个强大的 NIEHS基金的基础，建造了新的实验室，组装了多个预期的出生队列，开发了 一个成功的研究培训奖学金在儿科环境卫生，制定了一个强大的试点项目 该计划获得了世卫组织合作中心的称号，并取得了重大科学发现。 NIEHS核心中心的成立将加强我们的计划身份，维持我们的科学能力， 帮助我们培养年轻科学家的事业，他们是我们未来的领导者。

PROJECT SUMMARY/ABSTRACT The Icahn School of Medicine at Mount Sinai seeks to form a new Environmental Health Sciences Core Center-the Mount Sinai Transdisciplinary Center on Health Effects of Early Environmental Exposures. Our Center will leverage Mount Sinai's remarkable recent growth and build on our nationally and internationally recognized programs in children's environmental health. Our Center's mission is to understand how environmental exposures in early life influence health, development, and risk of disease and dysfunction across the life span - in infancy, childhood, adolescence and beyond. We will study the health impacts of chemical, genetic, nutritional, and social exposures and the interactions among them. Our approach will be transdisciplinary and highly translational. We will combine clinical, population-based and biological research with leading-edge genetics, epigenetics, and bioinformatics in the setting of a hospital-based, urban school of medicine. Through our clinical and community partnerships, we will translate our research findings into evidence-based approaches for disease prevention and treatment. To focus our research, our Center will establish three Research Groups: Endocrine and Metabolic Disruption, Neuro-Immunomodulation, and Oxidant-Antioxidant Imbalance. These Research Groups will bring together basic scientists, clinicians and population scientists committed to developing new, transdisciplinary research in environmental health The Research Groups will be supported by three Facility Cores: an Integrated Health Sciences Facility Core with Subcores in Exposure Biomarkers, Molecular Biomarkers, Clinical Population Access, and a Placenta Biobank; an Environmental Epidemiology, Statistics and Informatics Facility Core; and a clinically-oriented Phenotyping and Stress Assessment Facility Core. The Center supports a Pilot Projects Program, a Career Development Program, and a Community Outreach and Engagement Core, committed to bidirectional communication and partnership with the diverse and disadvantaged communities that Mount Sinai serves. Mount Sinai has attracted well-funded senior faculty who will be leaders in our Center, built a strong base of NIEHS funding, constructed new laboratories, assembled multiple prospective birth cohorts, developed a successful research training fellowship in pediatric environmental health, developed a robust Pilot Projects Program, gained designation as a WHO Collaborating Centre, and made significant scientific discoveries. Formation of an NIEHS Core Center will strengthen our program identity, sustain our scientific capacity, and help us build the careers of the young scientists who are our future leaders.