KOR Depression

描述（由申请人提供）：在人类抑郁症精神病理学动物模型中，κ阿片受体（KOR）与恐惧、威胁和快感缺乏的病因学有关。在此，我们建议使用正电子发射断层扫描在体内研究KOR，我们还将测量所有研究参与者的HPA轴活性。我们建议使用transdiagnosis方法招募多达N=50个无药物个体，测量他们的KOR选择性放射性配体[11 C]LY2795050分布容积（VT），相当于使用PET的KOR可用性，并研究KOR在介导抑郁表型的质量和严重程度中的作用。这个应用程序是为了响应NIMH的RDoC倡议，以澄清KOR在调解恐惧，威胁和奖励反应中的作用。

DESCRIPTION (provided by applicant): The kappa opioid receptor (KOR) has been implicated in the etiology of fear, threat, and anhedonia in animal models of human depression psychopathology. Herein, we propose to study the KOR in vivo using positron emission tomography, and we will also measure the activity of the HPA-axis in all study participants. We propose to recruit up to N=50 medication-free individuals using a transdiagnostic approach, measure their KOR-selective radioligand [11C]LY2795050 volumes of distribution (VT), an equivalent of KOR availability using PET and study the role of the KOR in mediating the quality and severity of the depressive phenotype. This application is in response to the RDoC initiative of NIMH to clarify the role of the KOR in mediating fear, threat, and reward responsiveness.