A Drosophila Model Investigates the Role of Metals in Initiating Urinary Stones

描述（由申请人提供）：本提案寻求在加州大学旧金山分校建立一个泌尿系结石疾病的跨学科研究中心。肾结石是一种良性泌尿系统疾病，每年影响数百万美国人。我们的研究发现，非钙金属可能在启动肾结石钙化中起关键作用。我们已经证明，结石形成背后的钙化过程可能在广泛的疾病中共享，包括动脉粥样硬化和骨质疏松症。因此，我们建立了一个跨学科合作网络来探索这些联系。这包括遗传学、金属代谢、高级成像和生理学方面的专家。我们提出的核心研究项目的重点是推进我们对金属如何在钙化和肾结石形成中发挥关键作用的理解，利用一种新的尿路结石疾病的黑腹果蝇模型。工作将与梅奥诊所的奥布莱恩泌尿学研究中心、巴克衰老研究所和奥克兰儿童医院研究中心的合作者共同完成。这个核心项目将汇集不同的学科和不同的机构，从一个新的和广阔的角度来理解泌尿系结石疾病。该提案的中心主任Marshall Stoller博士为领导团队带来了超过25年的跨学科研究和临床经验，并且作为UCSF泌尿结石部门的负责人，非常有资格运营该中心。我们的行政核心将支持一项教育计划，该计划将通过一系列研讨会，为泌尿系结石疾病的研究汇集更多不同的矿化观点，为该领域的研究发展新的对话和合作努力。该中心的建立将对推进良性泌尿外科领域的合作研究以及我们对泌尿结石疾病的认识和治疗产生重大影响。

DESCRIPTION (provided by applicant): This proposal seeks to develop a cross-disciplinary research center for the study of urinary stone disease at the University of California, San Francisco. Kidney stones are a benign urologic disease affecting millions of Americans annually. Our research has discovered that non-calcium metals may play a critical role in initiating kidney stone calcification. We have demonstrated that the calcification process underlying stone formation may be shared across a broad range of diseases, including atherosclerosis and osteoporosis. We have therefore established a network of cross-disciplinary collaborators to explore these connections. This includes experts in genetics, metal metabolism, advanced imaging, and physiology. Our proposed core research project focuses on advancing our understanding of how metals may play a critical role in calcification and kidney stone formation utilizing a novel Drosophila melanogaster model for urinary stone disease. Work will be performed in conjunction with collaborators at the O'Brien Urology Research Center at the Mayo Clinic, the Buck Institute for Research on Aging, and the Children's Hospital of Oakland Research Center. This core project will bring together different disciplines and different institutions to approach understanding urinary stone disease from a new and broad viewpoint. Dr. Marshall Stoller, the Center Director for this proposal, brings more than 25 years of cross-disciplinary research and clinical experience to the leadership team and as the head of the UCSF urinary stone division, is well qualified to run the center. Our administrative core will support an educational program that will bring together additional diverse perspectives on mineralization for the study of urinary stone disease with a series of workshops that will develop new dialogues and collaborative efforts for research in this field. Establishment of this center wil make a significant impact on advancing collaborative research in the field of benign urology and our understanding and treatment of urinary stone disease.