CRN4: Cancer Research Resources & Collaboration in Integrated Health Care Systems

描述（由申请人提供）：本申请是为了将HMO癌症研究网络（CRN）竞争性更新和转化为研究资源。CRN自1999年以来一直得到资助，为在非营利性综合卫生保健系统中开展癌症研究提供基础设施支持。该环境具有开展人口科学研究的优势，这些优势共同形成了开展癌症流行病学和卫生服务研究的独特、无与伦比的资源。这些优势包括由外部资助的研究小组和具有在这些环境中进行公共领域癌症研究的专业知识的研究人员；向其提供医疗保健的确定人口总数超过1 000万人；临床和行政数据系统，涵盖护理的大多数方面；在虚拟数据仓库（VDW）中发展和实施通用数据模型，以促进合作和多机构研究；并与临床医生和管理人员接触，以促进将研究成果转化为实践。我们计划在几个方面加强CRN，包括：通过实施分布式查询工具，建立一个信息学核心，专注于VDW的持续改进，以促进研究准备和合作研究，以及改进与癌症研究相关的现有和新的VDW领域的实施；确定和促进CRN独特定位的战略领域的研究（即预防和筛查；治疗和结果；生物标本和分子应用；沟通和决策；卫生保健质量和成本；传播和实施）；将CRN学者指导的初级调查员职业发展计划制度化；继续推行发展及先导研究计划，以支持先导研究及改善基础设施；推行外展及对外合作核心，以促进研究合作。这种持续的基础设施支持将使并促进研究人员继续访问大型综合交付系统，并激励作为国家首要学习医疗保健系统的持续发展。

DESCRIPTION (provided by applicant): This application is for a competitive renewal and transformation of the HMO Cancer Research Network (CRN) into a research resource. The CRN, which has been continuously funded since 1999, provides infrastructure support to conduct cancer research in the setting of not-for-profit integrated health care delivery systems. The setting has advantages for conducting population sciences research that collectively result in a unique, unparalleled resource for conducting epidemiologic and health services research in cancer. These advantages include externally-funded research groups with investigators with expertise in conducting public-domain cancer research in these settings; defined populations with a combined membership of over 10 million individuals for whom health care is provided; clinical and administrative data systems that capture most aspects of care; development and implementation of common data models in the Virtual Data Warehouse (VDW) to facilitate collaborative and multi-institutional research; and access to clinicians and administrators to facilitate translation of research findings to practice. We plan to enhance the CRN in several areas, including: Establishing an Informatics Core focused on continual improvement of the VDW through implementation of distributed query tools to facilitate preparatory-to-research and collaborative research studies, and improvement of existing and implementation of new VDW domains of relevance to cancer research; identification and promotion of research in strategic areas for which the CRN is uniquely positioned (i.e., Prevention & Screening; Treatment & Outcomes; Biospecimens & Molecular Applications; Communications & Decision-Making; Health Care Quality & Cost; and Dissemination & Implementation); institutionalizing a CRN Scholars mentored career development program for junior investigators; continuation of a Developmental and Pilot Studies Program to support pilot studies and to enhance infrastructure; and implementation of an Outreach and External Collaborations Core to facilitate research collaborations. This continued infrastructure support will enable and facilitate researchers' continued access to large integrated delivery systems and motivate continued evolution as the nation's premier learning healthcare systems.