Training in the Neurobiology of Neurodegenerative Disease

描述(由申请人提供)：我们请求继续支持我们的基础神经科学博士后培训计划，因为它与神经退行性疾病和中风有关。该计划与几个与帕金森氏病、阿尔茨海默病、肌萎缩侧索硬化症和中风相关的关键研究计划以及匹兹堡神经退行性疾病研究所密切结合在一起，该研究所现在位于一个新建的最先进设施内的连续空间内。精神障碍和神经艾滋病方面的额外方案进一步改善了环境。这笔赠款将使我们能够保持招聘最好的博士后学员所需的临界质量，包括未被充分代表的少数族裔学员，并提供最高质量的培训计划。我们的培训计划主要集中在基础和转化性实验室研究，这些研究很容易与神经退行性疾病和中风有关。主要研究顾问和一个单独的研究咨询委员会和培训补助金指导委员会共同承担指导和监测每个受训者的任务。所有受训人员都参加了四项补充其研究经验的活动：1)临床疾病神经生物学研讨会，2)每月研究讨论，3)一系列专业发展研讨会，4)至少一项外展活动。负责任的行为问题被整合到整个计划中。学员还根据需要参加课程，并有机会授课和观察临床实践。这33名培训教师是全校神经科学项目的成员，他们对神经退行性疾病和中风特别感兴趣。大多数教职员工在培训和研究方面都有丰富的经验，并得到了大量的拨款支持。此外，我们还包括了一个由9名初级教员组成的小组，他们有出色的承诺，并将与一名更资深的教员一起担任共同导师。目前，我们的培训教师指导了90多名博士后实习生(此外还有大量博士后学生)，其中约20人有资格获得NRSA支持。我们正在申请津贴，以支持最初的4名博士后实习生，在5年内逐渐增加到6名。我们相信，我们的培训计划为优秀的博士后实习生提供了一个机会，让他们为与神经退行性疾病和中风问题直接相关的职业生涯做准备。

DESCRIPTION (provided by applicant): We request continuing support for our postdoctoral training program in basic neuroscience as it relates to neurodegenerative disease and stroke. The program is closely integrated with several key research programs related to Parkinson's disease, Alzheimer's disease, ALS, and stroke, and to the Pittsburgh Institute for Neurodegenerative Diseases, now housed in contiguous space within a newly constructed state-of-the-art facility. Additional programs in psychiatric disorders and in neuro-AIDS further enhance the environment. The grant will permit us to maintain the critical mass needed to recruit the best possible postdoctoral trainees, including underrepresented minority trainees, and to offer a training program of the highest quality. Our training program focuses primarily on basic and translational laboratory research that can readily be related to neurodegenerative disease and stroke. The major research advisor and an individualized research advisory committee and the training grant steering committee share the task of guiding and monitoring each trainee. All trainees participate in four activities that supplement their research experience: 1) A seminars on the neurobiology of clinical disorders, 2) a monthly research discussion, 3) a series of professional development workshops, and 4) at least one outreach activity. Issues of responsible conduct are integrated into the entire program. Trainees also participate in courses as needed and have opportunities to teach and to observe clinical practice. The 33 members of the training faculty are members of the university-wide program in neuroscience with a particular interest in neurodegenerative disorders and stroke. Most of the faculty members have extensive experience in training and in research and have significant grant support. In addition, we have included a group of 9 junior faculty who have outstanding promise and will be available to serve as co-mentors in conjunction with a more senior faculty member. At present our training faculty supervise more than 90 postdoctoral trainees (in addition to a large number of pre-doctoral students), of whom about 20 are eligible for NRSA support. We are requesting stipends to support an initial complement of 4 postdoctoral trainees, increasing gradually to 6 over a 5-year period. We believe that our training program provides an opportunity for outstanding postdoctoral trainees to prepare for a career of direct relevance to issues of neurodegenerative disease and stroke.