High Performance Connectome Upgrade for Human 3T MR Scanner

描述(由申请人提供)：本提案的目的是支持西门子TIM Trio扫描仪的高性能升级。此次升级将大大增强明尼苏达大学正在进行的由NIH资助的成像研究，使研究人员能够充分利用标准3特斯拉扫描仪目前无法提供的高级神经成像功能，特别是利用由磁共振研究中心(CMRR)和马萨诸塞州总医院(MGH)的人类连接组(HCP)团队最近推出的先进方法。此次升级还将使CMRR能够继续在拟议的平台上开发HCP类型的方法，并继续支持世界各地许多(目前已超过60个，而且正在迅速增加)依赖CMRR开发和分发的脉冲序列和图像重建软件的其他网站，这些网站使用“客户对同行”的传输机制。拟议的升级是基于西门子最近宣布的新的3特斯拉扫描仪(Prisma)。PRISMA是为了应对两个HCP财团--由华盛顿大学和明尼苏达大学(CMRR)领导的吴明州财团以及MGH-UCLA财团--在神经成像方面取得的显着进展而开发的。HCP开发的方法运行在两台特殊的“Connectome”3T扫描仪上，带来了对脑成像的进步至关重要的新的和令人兴奋的功能，例如亚秒级全脑、高分辨率静息状态和任务功能磁共振成像，以及用于脑束成像和使用广泛Q空间采样确定微结构的高分辨率(~1 mm各向同性)扩散加权磁共振成像(DMRI)。

DESCRIPTION (provided by applicant): The aim of this proposal is to support a high performance upgrade for a Siemens Tim Trio scanner. The upgrade will greatly enhance ongoing NIH funded imaging research at the University of Minnesota, allowing investigators to fully utilize the advanced neuroimaging capabilities that are currently unavailable on standard 3 Tesla scanners, and, in particular, exploit the recently introduced advanced methodologies developed by the Human Connectome Project (HCP) teams at the Center for Magnetic Resonance Research (CMRR) and at Massachusetts General Hospital (MGH). This upgrade will also enable CMRR to continue HCP type methodology development on the proposed platform and continue the support of numerous (currently over sixty and rapidly increasing) other sites throughout the world that rely on pulse sequence and image reconstruction software developed and distributed from CMRR using "customer to peer" transfer mechanism. The proposed upgrade is based on a new, recently announced, 3 Tesla scanner (the Prisma) by Siemens. Prisma was developed in response to the significant gains in neuroimaging demonstrated by the two HCP consortia the WU-Minn consortium led by Washington University and University of Minnesota (CMRR) and the MGH-UCLA consortium. The HCP developed methods running on the two special "Connectome" 3T scanners, has brought new and exciting capabilities critical for advancements in brain imaging, such as subsecond whole brain, high resolution resting state- and task-fMRI, and high resolution (~ 1mm isotropic) diffusion weighted MR imaging (dMRI) for tractography and for microstructure determination using extensive q-space sampling.