Tumor Microenvironment/Angiogenesis Training Grant

描述（由申请人提供）：越来越多的证据表明，肿瘤微环境对癌症的发生和发展至关重要。肿瘤微环境由几种组分组成，包括肿瘤细胞、肌成纤维细胞、星状细胞、瘤周神经细胞、内皮细胞、免疫细胞和内分泌细胞，以及细胞外组分如细胞外基质。虽然人们认识到这些成分是肿瘤发生的介质，但对这些成分之间复杂的相互作用知之甚少。迫切需要研究原发肿瘤部位和转移性病变常见部位器官中肿瘤微环境相互作用的机制，以确定改善癌症治疗的潜在靶点，以及风险管理和预防。因此，我们认为，显然需要新的项目来培训研究生和研究生水平的个人，以了解和有效地研究有助于正常基质细胞转化为导致肿瘤进展和转移的活跃肿瘤微环境的复杂过程。 该提案要求提供资金，以支持每年8名学员（2名博士前，6名博士后），为期5年。该计划的目标是为那些将进行急需研究的个人提供综合培训，这些研究将调查导致肿瘤发生，进展，转移和复发的肿瘤微环境成分的分子和细胞异常。该计划是基于这样的想法，即在癌症形成的基质和上皮功能障碍领域的重大进展，临床相关性，将通过在细胞生物学，血管细胞生物学，细胞外基质生物学，癌症遗传学，免疫学和临床癌症研究领域有大量指导和经验的研究人员的共同努力得到加强。 肿瘤微环境/血管生成（TMA）培训计划涉及25名全职教职员工，他们都在TMA相关领域拥有课外支持计划和专业知识。Mukhopadhyay博士将担任该项目的主任。他是一位经验丰富的导师和培训项目负责人。他将得到Mark McNiven博士的协助，Mark McNiven博士因其在细胞生物学方面的专业知识而闻名于世，并拥有出色的培训记录。 相关性：尽管在癌症的诊断和治疗方面取得了巨大的进步，但我们还远远没有达到“根除癌症”的最佳目标。“这项培训计划将为下一代癌症研究人员提供一套完整的技能，以了解肿瘤细胞及其周围细胞的复杂相互作用。这些知识将用于改善癌症预防和治疗方法。

DESCRIPTION (provided by applicant): Accumulating evidence has shown that the tumor microenvironment is critically important for the initiation and progression of cancer. The tumor microenvironment consists of several components including tumor cells, myofibroblasts, stellate cells, peritumor nerve cells, endothelial cells, immune cells and endocrine cells, as well as extracellular components such as the extracellular matrix. While it is recognized that these components are mediators of tumorigenesis, the complex interplay of these components is poorly understood. Research efforts to investigate the mechanisms of tumor microenvironment interactions in the primary tumor site and organs that are common sites of metastatic lesions are critically needed in order to identify potential targets for improved cancer treatment, as well as risk management and prevention. Hence, we believe that there is a clear need for new programs to train individuals at the graduate as well as the postgraduate levels to understand and efficiently investigate the complex processes that contribute to the conversion of normal stromal cells to an active tumor microenvironment that leads to tumor progression and metastasis. This proposal requests funding to support is 8 trainees (2 predoctoral, 6 postdoctoral) each year for 5 years The program objective is to provide integrated training to individuals who will conduct critically needed research investigating the molecular and cellular anomalies of tumor microenvironment components that result in tumor initiation, progression, metastasis, and relapse. The program is based on the idea that major progress, of clinical relevance, in the area of stromal and epithelial dysfunction of cancer formation will be enhanced by a concerted effort of investigators who have had substantial mentoring and experience in the fields of cell biology, vascular cell biology, extracellular matrix biology, cancer genetics, immunology, and clinical cancer research. The Tumor Microenvironment/Angiogenesis (TMA) Training Program involves 25 full faculty members, all of whom have extramurally supported programs and expertise in TMA-related areas. Dr. Mukhopadhyay will serve as director of the program. He is an experienced mentor and training program leader. He will be assisted by Dr. Mark McNiven, who is known world-wide for his expertise in cell biology and he has an outstanding training record. RELEVANCE: Despite the tremendous advancements in the diagnosis and treatment of cancer, we are far from achieving our optimal goal to "eradicate cancer." This training program will program will provide the next generation of cancer researchers with an integrated set of skills needed to understand the complex interactions of tumor cells and the cells surrounding them. This knowledge will be used to improve cancer prevention and treatment methods.