Animal Models Core

人畜共患病和新出现的传染病对全球健康构成日益严重和非常现实的威胁， 我们必须扩大对这些疾病的发病机制和预防的了解。 由于人口密度的增加，接触家畜的机会增加 人口，以及野生动物挤入牲畜和人类频繁接触的有限区域。至 为了应对日益增长的传染病研究需求，成立了科布雷卓越中心 在蒙大拿州立大学(MSU)，目标是将蒙大拿州定位为全国领先的 人畜共患传染病。在过去的9年里，该中心取得了极其成功的成果， 基础设施发展(设施和设备)、初级调查员征聘和支助(7 科布雷项目、6名新员工和20个试点项目)，并组建了一个联合调查中心。 这些组成部分的协同作用为传染性疾病奠定了坚实的基础。 该地区的疾病研究。重要的是，这些努力促进了教师的职业发展和 创造了一批对传染病发病机制感兴趣和专业知识的新研究人员。 Cobre III的主要目标将是继续扩展动物的能力和用途 模型核心，并将其定位为长期可持续发展。将追求四个具体目标来解决 这些目标：具体目标1：为研究提供和维护最先进的设施 支持科布雷资助的试点基金以及所有其他中心和密歇根州立大学研究的动物模型 方案，包括进入动物资源中心(ARC)、小动物BSL-2和BSL-3 设施和大型动物ABSL-2设施；具体目标2：提供指导、指导和 鼓励、指导和促进中心对动物模型的高级战略使用的专业知识 密歇根州立大学的研究人员和其他生物医学研究人员；具体目标3：扩大、改进和 鼓励使用先进的小动物模型或相关的大动物模型进行生物医学研究 帮助调查人员选择更合适或更先进的模型，并通过改进战略 群体维持、畜牧业、遗传分析和生产；以及具体目标4：使用正在进行的 评估以指导动物模型核心的进一步改进和发展，以更好地满足用户的需求 需求，并帮助确保超越科布雷III的可持续性。积极、充满活力的 研究环境是跨学科协作。因此，在向可持续发展演变的过程中， Cobre III动物模型核心将为密歇根州立大学所有感兴趣的动物用户提供服务，从而建立 将导致长期研究活力的互动和合作。

Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent livestock and human contact. To address the growing need for infectious disease research, a COBRE Center of Excellence was established at Montana State University (MSU), with the goal of positioning Montana as a national leader in research on zoonotic infectious diseases. Over the past 9 years, the Center has been extremely successful, resulting in infrastructure development (facilities and equipment), recruitment and support of junior investigators (7 COBRE Projects, 6 new hires, and 20 Pilot Projects), and formation of a coiiesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for infectious disease research in the region. Importantly, these efforts have fostered faculty career development and have created a pipeline of new researchers with interest and expertise in infectious disease pathogenesis. The primary objectives in COBRE III will be to continue to expand the capabilities and use of the Animal Models Core, and position it for long-term sustainability. Four specific Aims will be pursued to address these objectives: Specific Aim 1: To provide and maintain state-of-the-art facilities for research involving animal models in support of COBRE-funded Pilot Grants, as well as all other Center and MSU research programs, including access to the Animal Resources Center (ARC), small animal BSL-2 and BSL-3 facilities, and a large animal ABSL-2 facility; Specific Aim 2: To provide instruction, mentoring, and expertise that encourages, guides, and fosters advanced strategic use of animal models by Center investigators and other biomedical researchers at MSU; Specific Aim 3: To expand, improve, and encourage use of advanced small animal models or relevant large animal models for biomedical research to help investigators select more appropriate or more advanced models and by improving strategies for colony maintenance, husbandry, genetic analyses, and production; and Specific Aim 4: To use ongoing assessment to guide further improvement and evolution of the Animal Models Core to better meet users' needs and to help ensure sustainability beyond COBRE III. One of the linchpins for an active, vibrant research environment is interdisciplinary collaboration. Therefore, in evolving toward sustainability, the COBRE III Animal Models Core will offer its services to all interested animal users at MSU, thus building the interactions and collaborations that will lead to long-term research vitality.