A prospective study of CFS following infectious mononucleosis in college students

摘要 大约12%的年轻人将在6个月内达到慢性疲劳综合征(CFS)的标准 传染性单核细胞增多症(IM)(Katz等人，2011年)。IM似乎是一种易感因素 一些罹患慢性疲劳综合征的人。许多候选的心理和生物风险因素 有人提出要解释这一现象，但几乎所有人都缺乏之前的预期数据 患者患上IM或CFS。一些学生在大学期间发展了即时通讯。很多学生 卫生服务让学生在身体状况良好时使用他们的服务(例如，在体育方面- 相关伤害和节育)。我们的研究将招收西北大学的学生 在医疗状况良好的情况下，以及在他们开发IM和 CFS。当学生身体健康时，我们会收集生物和心理数据，当他们发展IM时， 当他们发展成慢性疲劳综合征时。在3年的招聘期结束后，我们将继续跟踪 已发展为CFS 12个月的患者。我们将收集有关候选生物的数据 以及被认为与CFS的发展有关的心理因素，如既往的压力 生活事件、“行动倾向”、应对技能、自主神经功能障碍、细胞因子水平和严重程度 即时消息本身。我们建议的研究将比较这些疾病前(IM)和疾病后的预期变量 疾病(IM)数据在有和没有继续发展为CFS的学生之间。这项研究将能够 确定IM后CFS发生的危险因素。我们有独一无二的能力 针对IM的发展，对“圈养”和高危人群实施这项前瞻性研究 和CFS。

Abstract About 12% of young adults will meet the criteria for chronic fatigue syndrome (CFS) 6 months following infectious mononucleosis (IM) (Katz et al., 2011). IM appears to be a predisposing factor for some individuals who develop CFS. Many candidate psychological and biological risk factors have been proposed to explain this phenomenon, but almost all lack prospective data from before the patients became ill with either IM or CFS. Some students develop IM while in college. Many student health services have students who use their services when they are medically well ( e.g., for sports- related injuries and birth control). Our study will enroll Northwestern University (NU) students who use the university based health services when medically well, as well as after they develop IM and CFS. We will gather biological and psychological data when students are well, when they develop IM, and when they develop CFS. At the end of the 3 year recruitment period, we will continue to follow those who have developed CFS for 12 months. We will collect data regarding candidate biological and psychological factors thought to be related to the development of CFS, such as previous stressful life events, "action proneness", coping skills, autonomic dysfunction, cytokine levels and the severity of the IM itself. Our proposed study will compare these prospective pre-illness (IM) variables to post- illness (IM) data between students who do and do not go on to develop CFS. This study will be able to identify risk factors for the development of CFS following IM. We have the unique ability to implement this prospective study with a "captive" and high-risk population for the development of IM and CFS.