Molecular Mechanisms and Genetics of Autoimmunity COBRE

描述(由申请人提供)：俄克拉荷马州医学研究基金会的十年研究报告“自身免疫的分子机制和遗传学(GM 103456)在为理解本州自身免疫性疾病的分子和遗传学基础方面的发展提供了变革性的基础。Cobre提供指导、资金和基础设施支持，以启动多个独立的研究事业，并授予“非Cobre”计划或中心赠款，极大地扩大了俄克拉何马州的研究基础。OMRF和俄克拉何马州现在可以合法地声称自己是美国的自身免疫遗传学和基因组学中心。我们现在建议开发财务和运营独立的两个关键研究核心，这两个核心对我们以前的成功起到了重要作用。基因组学核心(以前的核酸核心)从一开始就是这个Cobre的一个组成部分。现在配备了下一代测序和高通量基因分型能力，该核心生成了40多个用户的研究项目所需的基因组数据。量化分析核心(QAC)是在第10年由两个现有核心合并而成，一个侧重于统计，另一个侧重于生物信息学。QAC使Cobre研究人员能够接触到由数据分析师、统计学家和生物信息学家组成的综合团队，提供从研究设计、功率估计、统计分析和高维数据建模的全方位支持。除了研究核心，我们的Cobre第三阶段还支持试点计划和管理核心。试点项目核心将通过一年的试点项目确定、支持和指导符合科布雷条件的初级科学家。我们将这些试点基金视为我们在俄克拉何马州基因组研究基地未来计划的基础。管理核心将为Cobre科学家提供行政支持，实施和扩大多学科浓缩计划，并评估试点项目的有效性。OMRF将通过持续和扩大对工资、资本设备、实验室空间和教师招聘的支持，继续与Cobre合作。我们相信，在Cobre第三阶段的支持下，OMRF和俄克拉何马州将拥有一个出色的基因组学中心。

DESCRIPTION (provided by applicant): The Oklahoma Medical Research Foundation's ten-year COBRE, "Molecular Mechanisms and Genetics of Autoimmunity (GM 103456) has been transformative in providing the foundation for growth in understanding the molecular and genetic basis of autoimmune diseases in our state. This COBRE provided mentoring, funding and infrastructure support to launch multiple independent research careers and the awarding of "non-COBRE" program or center grants, greatly expanding the research base in Oklahoma. OMRF and Oklahoma can now legitimately claim to be a "Center" for Autoimmunity Genetics and Genomics in the United States. We now propose to develop to financial and operational independence two key research cores that were instrumental in our previous success. The Genomics core (formerly the Nucleic Acids Core) has been a component of this COBRE since it's beginning. Now equipped with next generation sequencing and high-throughput genotyping capability, this core generates the genomic data needed for the research projects of over 40 users. The Quantitative Analysis Core (QAC) was formed in year 10 through a merger of two existing cores, one focusing on statistics and the other on bioinformatics. The QAC provides COBRE investigators with access to an integrated group of data analysts, statisticians and bioinformaticists offering a full range of support from study design, power estimates, statistical analysis, and high dimensional data modeling. In addition to the research cores our COBRE Phase III supports Pilot Program and Administrative Cores. The pilot project core will identify, support and mentor COBRE eligible junior scientists through one year pilot projects. We view these pilot funds as a fundamental to our plans for the future of our genomics research base in Oklahoma. The Administrative core will provide administrative support to COBRE scientists, implement and expand multidisciplinary enrichment programs and evaluate the effectiveness of the pilot projects. OMRF will continue to partner with this COBRE through sustained and expanding support of salaries, capital equipment, laboratory space and faculty recruitment. We are confident that with Phase III COBRE support OMRF and Oklahoma will have an outstanding Genomics Center.