The 5th US-EU Conference on Endogenous DNA Damage

描述(申请人提供)：第五届美国-欧盟内源性DNA损伤修复会议将于2014年11月在新墨西哥州圣达菲举行。这一系列会议的独特之处在于它关注细胞对自然形成的基因组损伤的反应，以及这些反应中的缺陷与与癌症易感性、神经缺陷和过早衰老有关的遗传疾病的关系。了解内源性DNA损伤对人类疾病的贡献，特别是癌症，以及与衰老相关的病理变化仍然是本次会议的主要主题。最近，关于癌症基因组突变的发生率和谱的信息呈爆炸式增长。这些研究揭示了出人意料的大量碱基替换，其中许多很可能是由持续的内源性DNA损伤引起的。这次会议的一个主要目标是促进对影响癌症中这种类型的基因组不稳定性的细胞过程的合作研究。内源性DNA损伤，特别是氧化DNA损伤，作为正常和加速衰老的驱动因素，以及对过早衰老综合征的研究，仍然是人们感兴趣的重要领域。来自DNA损伤反应缺陷的罕见遗传性人类疾病的见解继续阐明内源性DNA损伤与癌症、衰老和神经疾病之间的联系。为了促进将有关内源性DNA损伤的来源和修复的知识转化为改善全球人类健康的干预措施，本次会议将推动合作转化研究，重点是确定新的治疗靶点和开发治疗策略，这些治疗策略要么调节DNA修复途径以加强癌症治疗，要么延缓神经退化，或者减少与衰老相关的病理变化。2014年会议的一个关键目标是为不同背景的早期研究人员和高级研究人员提供一个环境，交流他们在相关科学主题上的最新成果，并建立未来的互动，这不仅将加强这一领域的许多基础科学和翻译研究努力，而且还将促进下一代研究人员的发展。毕晓普的洛奇牧场度假村和水疗中心是一个高品质的自给自足的会议场所，位于圣达菲城外。这 地点将最大限度地促进参与者之间的互动，确保实现促进美国和欧盟科学家之间富有成效的互动的目标。

DESCRIPTION (provided by applicant): The 5th US-EU Conference on Repair of Endogenous DNA Damage will be held in Santa Fe, New Mexico in November, 2014. The uniqueness of this series of meetings is its focus on the cellular responses to naturally formed genomic damage, and the relationship of defects in these responses to genetically inherited disorders associated with cancer predisposition, neurological deficits and premature aging. Understanding the contributions of endogenous DNA damage to human disease, in particular cancer, and the pathological changes associated with aging remains the major theme of this conference. Recently, there has been an explosion of information about the incidence and spectra of mutations in cancer genomes. These studies have revealed an unexpectedly large number of base substitutions, many of which are likely to be caused by persistent endogenous DNA damage. A major goal of this meeting is to foster collaborative research on the cellular processes that affect this type of genomic instability in cancer. The role of endogenous DNA damage, in particular oxidative DNA damage, as a driver of normal and accelerated aging and the study of premature aging syndromes remain important areas of interest. Insights from rare inherited human diseases with defects in the DNA damage response continue to illuminate links between endogenous DNA damage and cancer, aging and neurologic disease. To promote the translation of knowledge about the sources and repair of endogenous DNA lesions into interventions that improve global human health, this meeting will stimulate collaborative translational research focused on the identification of new therapeutic targets and the development of treatment strategies that either regulate DNA repair pathways in order to enhance cancer treatment or delay neurodegeneration, or reduce the pathological changes associated with aging. A key objective of the 2014 meeting is to provide an environment for both early career and senior investigators of diverse backgrounds to communicate their latest results on relevant scientific topics and establish future interactions that will not only strengthen the many basic science and translational research efforts in this arena, but also enhance the development of the next generation of researchers. Bishop's Lodge Ranch Resort and Spa is a high quality self-contained conference site that is located just outside the city of Santa Fe. This location will maximize interactions amongst participants, ensuring that the goal of promoting productive interactions between scientists in the US and EU is achieved.