MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT)

描述（由申请人提供）：心力衰竭是一个主要的公共卫生问题，治疗方案有限。许多心力衰竭患者出现机械不同步运动，并伴有心功能的进一步恶化。一些心衰和非同步化心衰患者可以从心脏再同步化治疗（CRT）中获益，但三分之一或更多的心衰患者选择以传统标准进行CRT治疗，却无法从中获益。该项目的主要目标是：1)开发和评估磁共振成像（MRI）和图像分析方法，以更好地预测使用心脏再同步化治疗（CRT）治疗伴有非同步化心衰的结果；2)使用成像衍生数据进行计算机建模，模拟非同步化对心功能的影响及其对CRT的反应。由于心力衰竭是一种重要的临床疾病，而目前用于预测CRT疗效的方法准确性有限，因此该项目具有潜在的临床意义。

DESCRIPTION (provided by applicant): Heart failure is a major public health problem, with limited treatment options. Many patients with heart failure develop mechanical dyssynchrony, with associated further deterioration in heart function. Some patients with heart failure and dyssynchrony benefit from cardiac resynchronization therapy (CRT), but a third or more of heart failure patients selected for treatment with CRT with conventional criteria fail to benefit significantly from it. The primary goals of this project are: 1) development and evaluation of magnetic resonance imaging (MRI) and image analysis methods to better predict outcome of the use of cardiac resynchronization therapy (CRT) for heart failure with dyssynchrony, and 2) use of the imaging-derived data for computer modeling of the effects of the dyssynchrony on cardiac function and its response to CRT. As heart failure is an important clinical condition, and as current means used to predict response to CRT have limited accuracy, this project is potentially clinically very significant.