The Child Heath Research Center

描述(由申请人提供)：波士顿儿童医院CHRCDA计划的目标是培养从事世界级研究的儿科医生-科学家，以改善美国和世界各地儿童的医疗保健。我们的学者将在儿童医院和其他哈佛联合医院和哈佛医学院的杰出科学家的指导下，进行以实验室为基础的基础和翻译研究。我们的计划是为了确保独立科学家的发展。在这项建议中，我们描述了一个包括强化指导、全面教学计划和确保学者的科学发展的计划。方案监督将由外部现场访问委员会和内部指导委员会提供。已经制定了方案自我评估和审查学术进展的计划。我们建议继续为四个学者职位提供经费。大多数奖学金获得者将获得为期两年的资助，除非他们在第一年获得独立的K-Level或其他资助。从历史上看，医学部为每位学者的大部分薪金部分提供了资金，因此K12的大部分资金用于支付用品和研究技术人员的费用。该部还在大多数年份资助了一个职位，以支持第五个学者职位。学者通常是讲师级别的教员，但处于独立职业发展早期的助理教授也有资格申请。奖学金获得者将在任何时候被考虑，从他们开始担任导师到他们被认为距离提交他们的第一个R级NIH奖学金或同等资助金还有两年的时间。学者们将在广泛的科学调查中工作。过去和现在的学者在核重新编程机制、疟疾抗原的结构生物学、病毒进入的生物化学、矮小基因发现、心脏畸形、局灶节段性肾小球硬化和家族性癫痫、T细胞发育等许多领域都有工作。这些研究将阐明基本的分子机制，并将导致在所有儿科疾病领域开发新的治疗方式，包括血液学/肿瘤学、内分泌学、肾脏病、传染病、免疫学、肺病学和神经学。

DESCRIPTION (provided by applicant): The goal of the Children's Hospital Boston CHRCDA Program is to develop pediatrician physician-scientists who are performing world-class research that will improve health care for children in this country and around the world. Our Scholars will be performing laboratory-based basic and translational research under the mentorship of outstanding scientists at Children's Hospital and other Harvard Associated Hospitals and Harvard Medical School. Our program has been established to ensure the development of independent scientists. In this proposal we describe a program that included intensive mentoring, a comprehensive didactic program, and a program to ensure the scientific development of Scholars. Programmatic oversight will be provided by an External Site Visit Committee and an Internal Steering Committee. Plans are in place for programmatic self-evaluation and for review of Scholar Progress. We propose to continue the funding of four Scholar positions. Most Scholars will be funded for two years, unless they secure independent K-level or other funding during their first year of Scholarship. Historically, the Department of Medicine has funded the majority of the salary component of each Scholar, such that most of the K12 funding is used to cover the cost of supplies and research technicians. The Department has also in most years funded a position to support a fifth Scholar position. Scholars will be faculty members most often at the rank of Instructor, but Assistant Professors who are early in the development of their independent careers will also be eligible to apply. Scholars will be considered at any point from the beginning of their Instructorship to the point where they are considered to be two years away from submitting their first R-level NIH grant or equivalent. Scholars will work in a broad range of scientific investigations. Past and present Scholars are working in areas such as the mechanism of nuclear reprogramming, structural biology of malaria antigens, biochemistry of viral entry, gene discovery in short stature, cardiac malformations, focal segmental glomerulosclerosis and familial epilepsy, T cell development and many other areas. These investigations will elucidate fundamental molecular mechanisms and will lead to the development of new therapeutic modalities in all areas of pediatric disease, including hematology/oncology, endocrinology, nephrology, infectious disease, immunology, pulmonology and neurology.