Automated Function Prediction (AFP 2014)

描述（由申请人提供）：我们提议在2014年夏季组织一次名为“自动化功能预测”的会议（AFP 2014）。会议将由两个部分组成，第一部分是一系列关于蛋白质功能研究的演讲（邀请和贡献）和讨论部分，重点是在功能注释中使用的计算方法的理论和实践。第二个组成部分将通过参与第二次功能注释关键评估（CAFA）来提供大规模的计算方法评估，这是一个受到高度重视的蛋白质结构预测CASP评估协议启发的实验。了解蛋白质的功能是在分子水平上理解生命的关键。它还为理解疾病提供了重要的见解，因为许多疾病是由于蛋白质功能的丧失、破坏或获得而产生的。然而，由于需要对已知蛋白质进行实验注释，快速增长的生物体测序数量对功能基因组学项目提出了挑战。因此，蛋白质功能预测研究对生物医学研究具有重要意义。AFP 2014将激发关于功能本体论、导致功能注释的实验、生物定位、预测功能的方法以及这些算法的有效性的讨论和想法/经验的交流。AFP 2014会议将与国际计算生物学学会（ISCB）的官方会议第22届分子生物学智能系统国际会议（ISMB）相关联。ISMB 2014将于2014年7月在马萨诸塞州波士顿举行，AFP 2014将作为特别兴趣小组会议。这不仅将确保ISCB社区的广泛参与，而且与独立会议相比还可以降低成本。通过组织CAFA挑战，我们的目标不仅是评估当前功能预测的方法，而且还为研究人员开发新的和更准确的技术提供激励，这些技术是该领域不断进步所必需的。会议组织者将大力鼓励高级和初级科学家（包括博士后和学生）的广泛参与以及多样性。与杰克逊州立大学建立合作关系。所要求的经费仅用于旅行津贴。

DESCRIPTION (provided by applicant): We propose to organize a meeting titled Automated Function Prediction in the Summer of 2014 (AFP 2014). The meeting will consist of two components, the first being a series of talks (invited and contributed) and discussion sections dedicated to protein function research, with an emphasis on the theory and practice of computational methods utilized in functional annotation. The second component will provide a large-scale assessment of computational methods through participation in the 2nd Critical Assessment of Functional Annotation (CAFA), an experiment inspired by a highly-regarded CASP assessment protocol for protein structure prediction. Understanding protein function is critical to understanding life at the molecular level. It also provides important insights into understanding disease since many conditions arise as a consequence of the loss, disruption or gain of protein function. However, the rapidly growing number of sequenced organisms poses a challenge for functional genomics projects because of the need to experimentally annotate known proteins. Therefore, protein function prediction research is important for biomedical research. AFP 2014 will stimulate discussion and the exchange of ideas/experience regarding functional ontologies, experiments leading to functional annotations, biocuration, methodologies for predicting function, and effectiveness of these algorithms. The AFP 2014 meeting will be associated with the 22nd annual international conference on Intelligent Systems for Molecular Biology (ISMB), the official conference of the International Society for Computational Biology (ISCB). ISMB 2014 will be held in Boston, Massachusetts, in July of 2014, with AFP 2014 as a Special Interest Group meeting. This will not only ensure wide participation from the ISCB community, but also reduce costs compared to a stand-alone meeting. By organizing the CAFA challenge, we aim to not only assess the current methodology for function prediction, but also provide incentive for investigators to develop new and more accurate techniques that are necessary for the continuous progress of the field. The organizers of the meeting will strongly encourage broad participation of senior and junior scientists (including post-docs and students) as well as diversity. Collaboration is established with Jackson State University. Funding is requested for travel allowances only.