Automated Function Prediction (AFP 2014)

描述(由申请者提供)：我们建议在2014年夏季组织一次题为自动化函数预测的会议(法新社2014)。会议将由两部分组成，第一部分是一系列演讲(应邀和来稿)和专门讨论蛋白质功能研究的部分，重点是在功能注释中使用计算方法的理论和实践。第二个组成部分将通过参加第二次功能注释关键评估(CAFA)来提供对计算方法的大规模评估，该实验的灵感来自备受推崇的CASP蛋白质结构预测评估协议。了解蛋白质的功能对于在分子水平上理解生命至关重要。它还为理解疾病提供了重要的见解，因为许多疾病是由于蛋白质功能的丧失、中断或获得而产生的。然而，快速增长的测序生物数量对功能基因组学项目构成了挑战，因为需要对已知蛋白质进行实验性注释。因此，蛋白质功能预测研究对生物医学研究具有重要意义。法新社2014将促进关于功能本体论、导致功能注释、生物定位、预测功能的方法和这些算法的有效性的实验的讨论和思想/经验的交流。法新社2014年会议将与第22届分子生物学智能系统国际会议(ISMB)联系在一起，ISMB是国际计算生物学学会(ISCB)的官方会议。ISMB 2014将于2014年7月在马萨诸塞州的波士顿举行，法新社2014将作为特别兴趣小组的会议。这不仅将确保ISCB社区的广泛参与，而且与独立会议相比，还将降低成本。通过组织CAFA挑战赛，我们的目标不仅是评估目前的函数预测方法，而且还鼓励研究人员开发该领域持续进步所需的更准确的新技术。会议的组织者将大力鼓励高级和初级科学家(包括博士后和学生)的广泛参与以及多样性。与杰克逊州立大学建立了合作关系。仅为旅行津贴申请经费。

DESCRIPTION (provided by applicant): We propose to organize a meeting titled Automated Function Prediction in the Summer of 2014 (AFP 2014). The meeting will consist of two components, the first being a series of talks (invited and contributed) and discussion sections dedicated to protein function research, with an emphasis on the theory and practice of computational methods utilized in functional annotation. The second component will provide a large-scale assessment of computational methods through participation in the 2nd Critical Assessment of Functional Annotation (CAFA), an experiment inspired by a highly-regarded CASP assessment protocol for protein structure prediction. Understanding protein function is critical to understanding life at the molecular level. It also provides important insights into understanding disease since many conditions arise as a consequence of the loss, disruption or gain of protein function. However, the rapidly growing number of sequenced organisms poses a challenge for functional genomics projects because of the need to experimentally annotate known proteins. Therefore, protein function prediction research is important for biomedical research. AFP 2014 will stimulate discussion and the exchange of ideas/experience regarding functional ontologies, experiments leading to functional annotations, biocuration, methodologies for predicting function, and effectiveness of these algorithms. The AFP 2014 meeting will be associated with the 22nd annual international conference on Intelligent Systems for Molecular Biology (ISMB), the official conference of the International Society for Computational Biology (ISCB). ISMB 2014 will be held in Boston, Massachusetts, in July of 2014, with AFP 2014 as a Special Interest Group meeting. This will not only ensure wide participation from the ISCB community, but also reduce costs compared to a stand-alone meeting. By organizing the CAFA challenge, we aim to not only assess the current methodology for function prediction, but also provide incentive for investigators to develop new and more accurate techniques that are necessary for the continuous progress of the field. The organizers of the meeting will strongly encourage broad participation of senior and junior scientists (including post-docs and students) as well as diversity. Collaboration is established with Jackson State University. Funding is requested for travel allowances only.