2014 Muscle and Molecular Motors Gordon Research Conference

描述（由申请人提供）：本提案的目的是帮助支持早期研究人员的注册和旅行，以参加将于2014年7月6日至11日在佛蒙特州西多佛举行的“肌肉和分子马达”国际研讨会（戈登研究会议）。本次会议的副标题和重点是“解决收缩生物学的分子机制。“这次会议的独特之处在于，科学家们聚集在化学机械耦合、单分子生物物理学、蛋白质生物化学、细胞生物学和器官生理学领域。将有关于（a）允许蛋白质做机械工作的结构元件的演示和讨论，（B）当马达在负载下时（即，动态工作条件），（c）马达如何被货物、翻译后修饰和辅助蛋白调节，（d）以及马达和细丝系统如何被靶向作为广泛传播的病理学的疗法（例如，心血管疾病和癌症）。因此，与会者不仅对了解电机如何工作感兴趣，而且对它们如何与其他电机和信号网络相互作用以及它们的基本生物物理参数如何影响细胞功能感兴趣。与会者将包括学术和工业科学家，他们正在利用细胞骨架马达在关键调控途径之间的位置，从而设计新药和小分子疗法。

DESCRIPTION (provided by applicant): The aim of this proposal is to help support the registration and travel of early-stage investigators to an international symposium (Gordon Research Conference) on "Muscle and Molecular Motors" to be held July 6 - 11, 2014 in West Dover, VT. The subtitle and focus of this conference is "Resolving the Molecular Mechanisms of Contractile Biology." The unique feature of this meeting is the assembly of scientists working on chemomechanical coupling, single-molecule biophysics, protein biochemistry, cell biology, and organ physiology. There will be presentations and discussions about (a) the structural elements that allow proteins to do mechanical work, (b) how motors are regulated and controlled when they are under load (i.e., dynamic working conditions), (c) how motors are regulated by cargos, post-translational modification, and auxiliary proteins, (d) and how motors and filament systems are being targeted as therapies for wide-spread pathologies (e.g., cardiovascular disease and cancer). Thus, attendees are not only interested in understanding how motors work, but how they interact with other motors and signaling networks, and how their fundamental biophysical parameters impact cell function. Participants will include academic and industrial scientists that are taking advantage of the position of cytoskeletal motors at the nexus of key regulatory pathways, allowing the design of new drugs and small molecule therapies.