Case Center for Synchrotron Bioscience

描述(由申请人提供)：同步加速器生物科学中心(CSB)在国家同步加速器光源(NSLS)和凯斯西储大学(CWRU)拥有最先进的设施和实验室，建议通过更新其P30中心拨款，继续在布鲁克海文国家实验室(BNL)开发和运营一套同步加速器光束线和相关技术。自1994年以来，在NIH(NCRR/NIBIB)的持续资助、NSF的大力支持以及与许多学术机构和BNL的合作下，该中心通过设计、建造和运营多条光束线，支持了一个大型的国际结构生物学用户社区。该中心通过持续升级、维护和操作光束线，为NSLS的500多名生命科学用户提供服务，这些光束线提供光子、先进的终端站仪器，以及对一系列最先进的同步加速器生物物理技术的用户支持和培训。在这份更新提案中，CSB将继续进行以下技术方面的工作：同步加速器X射线足迹、X射线光谱学和大分子结晶学。行政核心将支持这些核心，传播和培训核心将补充其活动。在研究基地，总体来说，三个核心， 我们确定了176个PLS和245个具体的资金来源(项目)，其中包括230个同行评审的项目赠款(约200个来自NIH)。我们建议支持145个大分子结晶学项目(100个PI)、52个X射线足迹项目(43个PI)和48个X射线光谱学项目(33个PI)以供更新。 显著增强该研究基地现有设施的机会是基于一个新的同步加速器环NSLS-II的启用所提供的千载难逢的机会。公务员事务局团队与BNL合作，已为该设施的新光束线获得资金。在更新期的第一部分，公务员事务局将完成光束线的设计、购买和制造设备，然后在授权期的中点完成安装，然后委托几条最先进的光束线。我们将在赠款期限结束前过渡到充满活力的用户计划，拥有强大的科学设施、积极的传播和培训计划以及新的科学成果。五年期间的成果将是一个中心，它将继续吸引世界级同步加速器生物科学研究的磁铁，远远超过现有的能力和生产力，可以持续许多年到未来。

DESCRIPTION (provided by applicant): The Center for Synchrotron Biosciences (CSB), with state-of-the-art facilities and laboratories at the National Synchrotron Light Source (NSLS) and at Case Western Reserve University (CWRU), proposes to continue its programs of developing and operating a suite of synchrotron beamlines and associated technologies at Brookhaven National Laboratories (BNL) through a renewal of its P30 Center grant. Since 1994, with continuous funding from the NIH (NCRR/NIBIB), significant support from NSF and in partnership with many academic institutions and BNL, the Center has supported a large, international structural biology user community through the design, construction, and operation of multiple beamlines. The Center serves over 500 life-science users at the NSLS through the continuous upgrade, maintenance, and operation of beamlines that provide photons, advanced end-station instrumentation, and user support and training for a range of synchrotron biophysics technologies at the state-of-the-art. In this renewal proposal, the CSB will continue technology sores for: synchrotron X-ray footprinting, X-ray spectroscopy, and macromolecular crystallography. An Administrative Core will support these cores and Dissemination and Training Cores will supplement their activities. In the Research Base, for the three cores overall, we identify 176 Pls with 245 specific sources of funding (projects) including 230 peer-reviewed project grants (~200 from NIH). We propose to support 145 projects in macromolecular crystallography (100 PIs), 52 projects in X-ray footprinting (43 PIs), and 48 projects in X-ray spectroscopy (33 PIs) for the renewal. The opportunity to considerably enhance the facilities available to this Research Base is based on a once in a generation opportunity provided by the opening of a new synchrotron ring, the NSLS-II. The CSB team, in collaboration with BNL has secured funding for new beamlines at this facility. During the first part of the renewal period, the CSB will complete beamline desig, purchase and fabricate equipment, and then by the mid-point of the grant period complete installation, then commission several state-of-the art beamlines. We will make the transition to vibrant user programs by the end of the grant period with robust scientific facilities, active dissemination and training program and novel scientific results. The outcome of the five-year period will be a Center that continues to be a magnet for world-class synchrotron biosciences research well beyond existing capabilities and productivity that can continue for many years into the future.