Repair after Neonatal Brain Injury

描述（由申请人提供）：该基金旨在利用先进的成像技术研究人类大脑发育成熟和网络组织的结构和功能相关因素，以及新生啮齿动物的类似相关因素，重点是确定修复的基本机制。该资助将包括三个项目和两个核心：项目1)新生儿期缺血性损伤后的修复-使用结构和代谢系列成像来评估损伤如何改变大脑，其对围产期损伤的反应，以及结构连接如何与神经发育结果相关。这个队列将包括接受低温治疗的婴儿。项目II)修复患有先天性心脏病的高危新生儿——在这一高危人群中存在大脑发育迟缓。利用结构和代谢成像，我们将确定这种发育障碍是否与大脑连接和功能结果异常有关。项目III)早期早产后的修复-我们的数据显示许多早产儿有小脑成熟异常，白质发育异常或进行性白质疾病伴感染。利用结构和代谢成像，我们将确定连接模式的改变是一致的还是可变的，是否有可能从这些损伤中恢复，以及连接是否被这些早期的子宫外生命事件永久或短暂地破坏。有一个数据管理行政核心，包括生物统计支助、预算监督、培训和研讨会。成像和神经行为核心（服务核心）将通过确保在不同测试时间点的方法标准化和成像采集跟踪来支持三个人体成像项目。此外，这个核心将提供神经行为

DESCRIPTION (provided by applicant): This grant proposes to study both structural and functional correlates of brain developmental maturation and network organization using advanced imaging techniques in our human populations and similar correlates in newborn rodents with a focus on defining basic mechanisms of repair. The grant will encompass three projects and two cores: Project I) repair after ischemic injury in the term newborn - using both structural and metabolic serial imaging to evaluate how the injuries have altered the brain, its response to injury in the perinatal period, and how structural connectivity relates to neurodevelopmental outcome. This cohort will include babies treated with hypothermia. Project II) repair in high risk newborns with congenital heart disease- there is delayed brain development in this high risk population. Using structural and metabolic imaging, we will determine whether this disorder of development is associated with abnormalities in brain connectivity and functional outcome. Project III) repair after early preterm birth - our data show many preterm infants to have abnormalities of cerebellar maturation, abnormalities of white matter development or progressive white matter disease with infection. Using structural and metabolic imaging, we will determine whether altered patterns of connectivity are consistent or variable, whether recovery from these insults is possible and whether connectivity is permanently or transiently disrupted by these early ex-utero life events. There is an administrative Core for data management including biostatistical support, budgetary oversight, training and seminars. The Imaging and Neurobehavior Core (Services Core) will support the three human imaging projects by ensuring standardization of methods and tracking of imaging acquisition at the various testing time points. In addition, this Core will provide Neurobehavioral testing at all of the follow-up visits, and will be responsible for tracking patients for all projets.