Murine GI Surgical Modeling Core

GI外科建模核心提供独特的小鼠外科服务(减肥和其他新的外科手术)。设立这一核心是为了加强解除武装、复员和重返社会方案调查员的调查工作，并提供否则不可行的研究途径。核心的主要理由在于，越来越多的小鼠具有与消化系统疾病相关或潜在相关的基因改变，以及研究遗传(或药物)操作的影响所必需的外科和实验技术的需求。这些程序需要技能和实践才能研究健康、无压力的小鼠。该中心拥有熟练的外科医生，能够调整一系列程序以满足VDDRC成员的特定需求，包括减肥外科程序、Barrett‘s食道和肝脏移植的手术模型以及缺血/再灌注损伤模型。使用手术模型获得的结果的质量直接关系到动物的总体健康。Core非常重视提供没有可避免的、不受欢迎的并发症的小鼠模型。手术前后的护理对手术的成功与手术本身同样重要。CORE的总体目标是提供小鼠减肥手术模型，使用的程序旨在反映在人类身上进行的手术，肝脏移植，以及适应VDDRC成员需求的独特定制手术模型。实现这一目标的核心是： 1.提供小鼠减肥手术模型，应用于基础研究和转化性研究。 2.建立小鼠Barrett‘s食道、肝和小肠移植模型。 3.提供围手术期护理，以确保动物健康和没有过度应激。 4.对调查人员进行专门外科手术方面的培训。 5.通过制定新的程序，满足复员方案调查人员的需要。 该核心与VDDRC的其他核心、老鼠代谢表型中心(MMPC)、糖尿病研究和培训中心以及动物护理司密切互动，以确保并最大限度地有效利用资源和人员，并加强跨学科合作。

The GI Surgical Modeling Core provides unique murine surgical services (bariatric and other novel surgical procedures). This core was established to enhance the investigative efforts of the VDDRC investigators and provide avenues of research that otherwise would not be feasible. The primary rational for the core rests in the growing number of mice having genetic alterations with relevance or potential relevance to digestive diseases and the need for surgical and experimental techniques that are necessary to study the impact of genetic (or pharmacologic) manipulations. The procedures require skill and practice in order to study healthy, unstressed mice. The core has skilled surgeons that are capable of adapting a range of procedures to suit specific needs of VDDRC members including bariatric surgical procedures, surgical models for Barrett's esophagus and liver transplantation and ischemia/reperfusion injury models. The quality of the results that are obtained using surgical models is directly related to the general health of the animal. The Core has placed significant emphasis on providing murine models that are free of avoidable, undesired complications. Pre and post-operative care is as important to the success of the procedure as the surgical procedure itself. The overall goal of the core is to provide murine models of bariatric surgery using procedures that are designed to reflect those performed in humans, liver transplantation, and unique customized surgical models adapted to the needs of VDDRC members. To achieve this goal the core: 1. Provides mouse bariatric surgery models with application to basic and translational research. 2. Provides mouse models of Barrett's esophagus and liver and small bowel transplantation. 3. Provides peri-operative care to ensure that animals are healthy and free of undue stress. 4. Trains investigators in specialized surgical procedures. 5. Responds to the needs of VDDRC investigators through development of new procedures. The Core interacts closely with other VDDRC Cores, the Mouse Metabolic Phenotyping Center (MMPC), the Diabetes Research and Training Center, and the Division of Animal Care to ensure and maximize efficient use of resources and personnel and enhance interdisciplinary collaboration.