Center for American Indian and Alaska Native Diabetes Translational Research

美国印第安人和阿拉斯加原住民(AI/ANS)被诊断为糖尿病的可能性是美国普通人群中其他人的2.3倍，而且相关的过早死亡率也很高。科罗拉多大学丹佛分校(UCD)的研究人员为与AI/AN社区和那些为他们服务的人合作做好了独特的准备，通过翻译研究解决与糖尿病相关的健康差距。为响应RFA DK-10-009，我们建议建立P30美洲印第安人和阿拉斯加原住民糖尿病转化研究中心(CAIANDTR)。CAIANDTR将在与NIDDK的翻译研究议程相关的领域提供地方、区域和国家的核心服务和咨询，这些领域专门针对Al/ANS，但可推广到普通人口的其他部分。我们有四个具体目标。1)提供一个管理结构，促进专门针对改善糖尿病相关健康的翻译研究的卓越表现。这一核心将包括试点、可行性和丰富计划；2)召集一个由UCD教员资助的研究基地；3)研究所和工作人员4个资源核心(参与；技术；实施、传播和传播；以及可持续性)，旨在促进具有重大科学和规划重要性的多学科、有文化根基、以问题为导向的翻译研究计划，以及4)作为全国其他寻求与AI/AN社区合作的研究人员的国家资源核心，以及那些努力在农村和其他种族/少数民族人口中开展糖尿病翻译研究的人。需要的问题是不言而喻的，也是令人信服的。印度卫生系统已经准备好建立糖尿病预防和治疗服务，但寻求关于循证做法的指导，以改善其结果。UCD拥有丰富的研究和技术援助资源，通常与糖尿病翻译研究相关，特别是与人工智能/ANS相关。我们在全国范围内进入人工智能/人工智能社区，与消费者、提供商、规划者、服务机构、倡导者、政策制定者、项目资助者和其他科学家建立了广泛的合作伙伴关系。但是，要利用这种罕见的机会汇聚，需要协调除本P30等机制以外通常无法获得的资源。通过这种方式，我们将解决糖尿病相关的健康差距，在这个国家，当然，如果不是世界上，也是最高风险人群中。

American Indians and Alaska Natives (AI/ANs) are 2.3 times more likely to be diagnosed with diabetes than others in the U.S. general population-and also to suffer from high rates of related premature mortality. Researchers at the University of Colorado Denver (UCD) are uniquely prepared to collaborate with AI/AN communities and those who serve them in tackling diabetes-related health disparities through translational research. In response to RFA DK-10-009, we propose to establish a P30 Center for American Indian and Alaska Native Diabetes Translational Research (CAIANDTR). CAIANDTR will provide core services and consultation locally, regionally, and nationally in areas relevant to the NIDDK's translational research agenda, specific to Al/ANs but generalizable to other segments of the general population. We have 4 specific aims. 1) Provide an administrative structure that promotes excellence in translational research specific to improving diabetes-related health. Included within this core will be Pilot and Feasibility and Enrichment programs; 2) Convene a Research Base of funded UCD faculty; 3) Institute and staff 4 Resource Cores (Engagement; Technology; Implementation, Dissemination, and Diffusion; and Sustainability) designed to facilitate a multidisciplinary, culturally grounded, problem-oriented translational research program of major scientific and programmatic importance, and 4) Serve as a National Resource Core for other investigators around the country seeking to work with AI/AN communities, as well as to those struggling to pursue diabetes translational research in rural and other racial/ethnic minority populations The timing is ideal for a diabetes translational research center focused on AI/ANs. Issues of need are self-evident and compelling. The Indian health system is primed to institute diabetes prevention and treatment services but seeks guidance in regard to evidence-based practices to improve their outcomes. UCD hosts a rich array of research and technical assistance resources relevant to diabetes translational research, generally, and to AI/ANs specifically. We have a nationwide reach into AI/AN communities, with extensive partnerships with consumers, providers, planners, service agencies, advocates, policy-makers, program funders, and other scientists. But capitalizing on this rare confluence of opportunities requires the coordination of resources not typically available other than through mechanisms such as this P30. In this way we will address the diabetes-related health disparities in a population with the highest risk in this country, certainly, if not the world.