Neural Coding of 3D Object and Place Structure in Two Cortical Pathways

项目总结 这个项目的长期目标是了解大脑是如何处理关于 地点-风景和室内-以及这与大脑处理关于 物体。我们将测量处于较高处理阶段的神经元与物体和位置相关的反应 两条主要的脑通路：(1)腹侧视觉通路传统上被认为是一种客体通路， 但我们的初步数据显示，它也强烈地从事于景观和室内的表现， 从与物体相关的加工到与位置相关的加工，具有背外侧-腹内侧斜率。(2) 最近发现的顶叶-内侧颞叶通路主要处理位置信息，并终止于 副海马区皮质。我们将使用数学分析来理解对象和位置信息是如何 由这两条通路中的神经元编码。我们预计这一结果将产生以下科学影响： 1.这种对复杂位置形状的第一次分析是在单个神经元和 神经元将加深对大脑感知、理解、相互作用和 在风景和室内导航，补充了之前在大脑成像水平上的研究。 2.分析比较将阐明编码机制是如何专用于非常不同的结构的 物体和场所的特征和生态作用。 3.腹侧通路和顶内侧通路形状编码机制的分析比较 增加对不同视觉功能如何在大脑中分布的理解。 4.客体和地点编码的结合研究将引导我们进一步研究这两个要素是如何结合的 在视觉场景的整体感知上。

Project summary The LONG-TERM GOAL of this project is to understand how the brain processes visual information about places-landscapes and interiors-and how that compares to brain processing of visual information about objects. We will measure object- and place-related responses of neurons in higher processing stages within two major brain pathways: (1) The ventral visual pathway is traditionally considered to be an object pathway, but our preliminary data show that it is also strongly engaged in representation of landscapes and interiors, with a dorsolateral-ventromedial gradient from object-related processing to place-related processing. (2) The recently recognized parieto-medial temporal pathway primarily processes place information and terminates in parahippocampal cortex. We will use mathematical analysis to understand how object and place information is encoded by neurons in these two pathways. We expect the results to have the following scientific impacts: 1. This first analysis of complex place shape is encoded at the level of individual neurons and groups of neurons will deepen understanding of brain mechanisms for perceiving, understanding, interacting with, and navigating through landscapes and interiors, complementing previous research at the brain imaging level. 2. Analytical comparison will elucidate how coding mechanisms are specialized for the very different structural characteristics and ecological roles of objects and places. 3. Analytical comparison of shape coding mechanisms between the ventral and parieto-medial pathways will increase understanding of how different visual functions are distributed across the brain. 4. Combined study of object and place coding will lead to future research on how these two elements combine in overall perception of visual scenes.