Colorado Clinical and Translational Sciences Institute

当今医学最大的挑战之一是高效、无缝和安全地翻译生物医学 改善人类健康的临床应用研究发现。新方法、新技术 集成的信息系统为发现和发展翻译服务提供了前所未有的希望 成功；然而，巨大的障碍继续扰乱我们迅速将发现转移到 临床实践，包括我们研究过程的效率、成本和效果。科罗拉多州 成立于2008年的临床与转化科学研究所(CCTSI)解决了这些挑战，并 改变了我们的机构研究基础设施。在这份申请中，科罗拉多大学丹佛分校 (CU-D)和我们的合作机构(CU-Boulder和科罗拉多州立大学[CSU]，六家主要医院 以及医疗保健组织和当地社区)将通过以下五个方面重新设计CCTSI 战略目标：1)丰富和扩展我们的临床和翻译综合全州学术之家 研究。2)建立新的临床研究管理战略，以加强质量、安全、效率、 成本效益和创新团队科学，包括实施新的软件系统和工作 流动。3)集中和加强我们出色的资源、服务和技术的交付以及 在适当的情况下，向调查人员收取费用。4)灌输社区参与的关键概念 进入翻译研究的全领域。5)增加翻译研究人员的能力 通过广泛的课程提供教育、培训和职业发展的机会。一次严格的追踪， 与正式质量和过程改进计划相结合的评估和评估计划 嵌入CCCTSI将确保最高效、最具成本效益和最具创新性地使用我们的宝贵资源 资源，同时保护我们研究参与者的安全。这些计划将集中在以下地点之一 国内最新的生物医学研究、教育和临床企业，CU Anschutz Medical 校园里有我们的学校、研究实验室、三家医院和一家生物医学中心 企业园区为我们的成功创造了理想的环境。 相关性(请参阅说明)： 这个项目与公共健康的相关性在于我们有能力帮助研究人员取得重要发现 并将其转化为人类疾病的新治疗方法、预防和治疗方法。我们也会提供帮助 研究人员找到了将这些疗法引入社区环境的方法，使我们全州的人们受益 和国家。

One of medicine's greatest cirallenges today is the efficient, seamless and safe translation of biomedical research discoveries into clinical applications that improve human health. New methodologies, technologies and integrated information systems offer unprecedented promise for discovery and growth of translational successes; however significant barriers continue to confound our ability to rapidly move discoveries into clinical practice, including the efficiency, cost and effectiveness of our research processes. The Colorado Clinical and Translational Sciences Institute (CCTSI), created in 2008, has addressed these challenges and transformed our institutional research infrastructure. In this application, the University of Colorado Denver (CU-D) and our partner institutions (CU-Boulder and Colorado State University [CSU], six major hospitals and health care organizations and local communities) will re-engineer the CCTSI through the following five Strategic Goals: 1) Enrich and expand our integrated statewide academic home for clinical and translational research. 2) Institute new clinical research management strategies to strengthen quality, safety, efficiency, cost effectiveness and innovative team science, including implementing new software systems and work flows. 3) Centralize and enhance the delivery of our outstanding resources, services and technologies and institute charge-backs to investigators where appropriate. 4) Infuse key concepts of community engagement into the full spectrum of translational research. 5) Increase the translational research workforce capacity through a broad curriculum of education, training and career development opportunities. A rigorous tracking, assessment and evaluation program coupled to a formal quality and process improvement program embedded in the CCCTSI will ensure the most efficient, cost-effective, and innovative use of our precious resources, while protecting the safety of our study participants. These programs will be centralized at one of the newest biomedical research, education and clinical enterprises in the nation, the CU Anschutz Medical Campus in which adjacencies of our schools, research laboratories, three hospitals and a biomedical corporate park create the ideal environment for our success. RELEVANCE (See instructions): The relevance of this project to public health lies in our ability to help researchers take important discoveries and translate them into new treatments, preventions and cures for human diseases. We also will help researchers find ways to bring these therapies into the community setting to benefit people across our state and country.