Investigating the interaction between BDNF and sex steroid hormones during adolescent development: relevance to schizophrenia

精神分裂症首次出现在青春期后期的临床上。性激素和生长因子，如脑源性神经营养因子（BDNF），都参与了青少年大脑向成人形态的塑造。这些系统的改变可能有助于精神分裂症中看到的结构变化。这个项目将研究BDNF和性激素在青春期小鼠大脑发育中的相互作用，以及与精神分裂症相关的行为反应。

Schizophrenia first appears clinically during late adolescence. Sex hormones as well as growth factors such as Brain derived neurotrophic factor (BDNF) are involved in shaping the adolescent brain to its adult form. Alterations to these systems may contribute to structural changes seen in schizophrenia. This project will investigate the interaction of BDNF and sex hormones in the development of the adolescent mouse brain, and behavioural responses with relevance to schizophrenia.